This has been an important year for the study of heart failure with advances being made on a number of fronts: in pharmacological therapy, surgery and the use of mechanical devices. In addition, we are now in a position to evaluate properly the results of a number of major trials and in this volume the editor presents a critical analysis of these findings. Included here are discussions of nine recent studies including the CHARM, EPHESUS, LIDO and OVERTURE trials, the latest studies of beta-blockers (COMET and CAPRICORN), TNF alpha-inhibitors (ATTACH) and endothelin antagonists (RITZ-4). Also reviewed are the recent studies of devices used in resynchronization therapy (MIRACLE and COMPANION), cardiac splints (ACORN) and also surgical procedures such as CABG (the STITCH trial). This new addition to the 'Year in' series is one of the most comprehensive reviews of clinical research dedicated to heart failure currently available.