The 30a papers of this two-volume proceedings were first presented at the First International Conference on BioMedical Engineering and Informatics, held in May 2008 in Sanya, Hainan, China. The papers are grouped by session topic, with major themes that include computational genomics and proteomics; artificial intelligence, machine learning and data mining; biomedical modeling; and biomedical sensors, device, instrumentation, artificial organs, and nano- technologies. The topic represented by the most papers was that of biomedical imaging, image processing, and visualization, with individual papers describing specific research and processes, for example, the automatic thresholding of Micro-CT trabecular bone images, or the multimodality medical image registration made possible using the hybrid optimization algorithm. There is an author index, but no subject index.