There's only so much you can do for a book this size with subject matter this dense. It's encyclopedic. There are sections that do more concept explanations but much of the book winds up being almost a glossary of terms. It isn't organized alphabetically, though, but by body system. Further complicating its use as a reference, the index isn't comprehensive enough.
I have this book in digital and hardback forms and haven't found a way in the past 2 years of making it easy to read. The hardback physical version weighs 7 lbs. The weight of it actually impairs circulation to your legs if you read it in your lap. It's hard to find a bag that can carry it if you need to take it somewhere to study. The complications are endless. The kindle version can be clunky to navigate or gauge progress in because it considers sections within a chapter to be the actual chapter in certain devices (ie. the Kindle Paperwhite I bought so I wouldn't have to kill my eyes reading this and other such monsters). Imagine, you have '5 minutes left in the chapter' for 2 hours and find you've only just completed the first section of said chapter, which is only about 15% of the entire chapter.
As with any written work there are issues with formatting, grammar, word choice, and punctuation. It never makes me feel better to see a book with so many editions and reworks has at least as many errors as a book with only one or two editions. They've also made the expert decision to put answers to in chapter questions and chapter summaries online and not into the admittedly already excessively huge book. This makes things disjointed for me and adds unnecessary steps that I'm not going to take if I'm trying to conquer the reading required for a 20+ chapter exam.
All in all, I'm sure there are worst med/surg books but I can't say I enjoyed using this one at all.