Well, I've reread this volume, and I have to say, it still stands as a great first book in the series. The Book of Drachma and all the adventure that Shepperton implies can be found here in the first book as an introduction. But more than that, it is the beginning of a grand saga that introduces characters and drama that you will keep with you for life. I have written five volumes, and am writing the sixth. Although it is tempting to say that the sixth will be the last - you never know!
Just to let you know, the book starts in 1992, with a cardiologist who gets called to see his patient in the middle of a blizzard and finds the youth in extremis, and he must obtain the services of a cardiac surgeon. All the while, he is getting messages that he is needed in another place and time, messages which he finds it more and more difficult to ignore.
In the fifteenth century, in the year 1492, we find another physician, who also gets called out in the middle of winter, in the middle of the night to see to his own patient, who may be dying. And what does he have to offer in this era well before any knowledge of germ theory, antibiotics, effective respiratory therapy or even concepts such as X-rays, EKGs or labs? Would it be possible to obtain help from the future? Well there you have the beginning of the epic adventure.
Even though Laminar Flow (and the following books) have gone through some changes, I would say that the story stays true, and you can just relax, and get lost in the tale of medicine in two times and places.