Designing Multi-Target Drugs

by J. Richard Morphy (Editor), C. John Harris (Editor), David E. Thurston (Series Editor)

Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date and their application to future MTDD.

394 pages, Hardcover

First published June 30, 2012

Reviews

[Vladimir · Rating 5 out of 5]

If you are interested in multi-target drug design, polypharmacology and related fields - this is the book that should be on your table.
This book is a not a naive selection of articles, but the book with a spine: the topics covered complete each other, every chapter has practical examples, it's not "very hard" because it's mostly written by the pharma folks, they don't like to wonder around and pour a lot of water, just facts.

I am greatly impressed by the book, yet little drawback - the last chapters are examples of drug candidates development lack colorful visualization, I would represent the multitarget optimization strategies using tree and coloring important parts of the molecule, even more - I would probably create interactive tree online.