Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

by Robert R. Crichton

This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

240 pages, Hardcover

First published February 3, 2006

About the author

Robert R. Crichton graduated in Biochemistry from the University of Glasgow, Scotland, in 1963/66. After carrying out postdoctoral research at the Max Plank Institut für Biochimie, Munich, Germany, he moved to the Université Catholique de Louvain, Belgium in 1973, where he has been a professor of Biochemistry in the Department of Chemistry. His main research interests are in the inorganic biochemistry of iron and related metals.