Worm (Table of Contents/official summary/TvTropes/Reddit/post-interview) is addictive superhero SF posing as fantasy; it is long, of consistently high quality, and features a huge amount of imaginative powers with equally imaginative applications & combos (the protagonist usage of bugs, as impressive as it is, is only one of many possible examples, although I particularly like the Regent & Shadow Stalker incident as an example of social-engineering/hacking); the setting excellently rationalizes the standard superheroes vs supervillains setup (which as often observed, makes little sense prima facie). The series opens in the smallest possible setting, the geeky introverted protagonist Taylor being bullied in school, steps logically towards a life of crime as a supervillain while trying to do the right thing (and being manipulated by multiple parties, some prescient) and slowly expands to multiversal scope with an appropriately epic & bittersweet ending. (Reminds me of Watchmen.) Or to borrow from the official summary:

An introverted teenage girl with an unconventional superpower, Taylor goes out in costume to find escape from a deeply unhappy and frustrated civilian life. Her first attempt at taking down a supervillain sees her mistaken for one, thrusting her into the midst of the local ‘cape’ scene’s politics, unwritten rules, and ambiguous morals. As she risks life and limb, Taylor faces the dilemma of having to do the wrong things for the right reasons...Readers should be cautioned that Worm is fairly dark as fiction goes, and it gets far darker as the story progresses. Morality isn’t black and white, Taylor and her acquaintances aren’t invincible, the heroes aren’t winning the war between right and wrong, and superpowers haven’t necessarily affected society for the better. Just the opposite on every count, really. Even on a more fundamental level, Taylor’s day to day life is unhappy, with her clinging to the end of her rope from the story’s outset. The denizens of the Wormverse (as readers have termed it) don’t pull punches, and I try to avoid doing so myself, as a writer. There’s graphic language, descriptions of violence and sex does happen (albeit offscreen).

I recommend reading single arcs at a time: calling the whole thing 'Worm' is a bit of a misnomer, it'd make much more sense to group a few arcs and call them individual novels in the 'Worm Saga' or something. Length-wise, it's upwards of a million words, and according to my arbtt logs (using the rule 'current window $title =~ [/.* Worm - Iceweasel/] ==> tag Worm'), took me 37 hours & 42 minutes over 5 days to read.

The work is not perfect. The opening is perhaps too slow: the first fight with Lung, which hooked me, took a while to happen as it only really starts in ch4. In the middle, I suspect there was perhaps too much material devoted to the Slaughterhouse Nine arc and not enough to later plot arcs like Taylor joining the heroes or dealing with later Endbringers. Further, there's so many characters that a binge read is a good idea, but during a binge, the fights can blur together and become exhausting, suggesting Worm may spend too much time on that. Some good parts, like characters having reasons to be bad, are taken to an extreme where it seems like every character, no matter how mundane, must have a backstory explaining how their environment/society made them evil (even for characters like Emma where such a cause is unnecessary). But the flaws are relatively small and hopefully will be addressed in the editing process. I look forward to reading Wildbow's Pact when it finished, and I think I'll check out some of the fanfics like Cenotaph .

I read Worm after it was finished and I continued to see positive reviews of it, such as Eliezer Yudkowsky:

...I commend to you...the just-completed story Worm, which is roughly 1.75 million words in 30 volumes. The characters in Worm use their powers so intelligently I didn't even notice until something like the 10th volume that the alleged geniuses were behaving like actual geniuses and that the flying bricks who would be the primary protagonists and villains of lesser tales were properly playing second fiddle to characters with cognitive, informational, or probability-based powers...Doing this so smoothly that I don't even notice because my brain considers the resulting world to be 'normal' really ought to deserve some kind of epic bonus points....There are stories which are better than Worm, and stories which were written faster than Worm, but I don't know of any epic which was ever written faster and better than Worm.

Other reviews include Joshua Blaine:

...a self consistent and expansive Super-hero universe, and with a ton of unique and powerful abilities, I've really been enjoying it. The story is Worm, and It's easily one of my favorite web stories in awhile, and very dark (especially as the story progresses further).

iDante:

I've been reading this awesome web serial called Worm. Highly recommend if you want some action and suspense. There's a bit of rationality business in there as well, but it's spaced out and the story is long. I see it's been recommended previously on here as well.

Vaniver:

Caveat: Worm is really dark. The characters are clever, the protagonist makes the most out of a superpower that seems mediocre at first glance, and there are enough twists and turns that I would look at the clock and realize that I'd been reading for six hours. (Worm is really long, so if you're the sort of person who has to keep reading fiction be warned that it will eat a week or two.) But, despite those positives, terrible things happen to everyone always. I found it similar to Game of Thrones in that it was engaging but depressing, and unlike GoT where new characters are introduced, dance about, and then die, in Worm there's a clear protagonist who, as far as I can tell, always wins eventually. I also found the superhero fight sequences less engaging as time went on - but they can be skimmed with little loss.

and Ritalin:

Indeed. Although, frankly, what I've seen of Worm so far seems to designate it as very similar to my idea of Hell; every accomplishment is either made moot or cost something irreplaceable and possibly of superior value, every victory is short-lived, every mistake is paid for dearly. Every situation is desperate, every problem urgent. By the time a conflict reaches its resolution, another is at its peak, and two more are right around the corner. Perhaps it's even worse; hardship, instead of building character, corrupts it. For the characters, it must be like a nightmare they can't wake up from.