By mid-March 1666 the city of Cambridge marked six weeks without a single plague death. The university reopened, and Newton returned to his rooms on or around March 20. Then, on Wednesday, June 6, Jane Ellingworth, a seamstress living on Penny Farthing Lane, felt poorly. Her father brought her a cup of ale and urged her to bed. She died the next day. The infection spread, with deaths reaching double digits in the city within two weeks.

