The traditional vaccine, vaccinia, has a rate of bad reactions, including brain disease and death, that probably makes it unacceptable by modern standards of pharmaceutical safety. About one in five people couldn’t receive the vaccine under current rules. The vaccine is a live virus, and it can sicken or kill people who have lowered immune systems. Today, many people have lowered immunity, including those who are taking immunosuppressive drugs, such as people in chemotherapy or people with inflammatory diseases. Many people also have lowered immunity because they are HIV-positive. The vaccine
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