For an average of three weeks, participants undergo a lengthy daily regimen, spending up to eight hours a day in a sauna, interspersed with exercise, and taking massive doses of vitamins, especially niacin. In large amounts, niacin can cause liver damage, but it will also stimulate the skin to flush and create a tingling sensation. The church says that this is evidence of drugs and other toxins being purged from the body. Although many in the medical profession have been hostile to the Purification Rundown, citing it as a fraud and a scam, Hubbard thought he deserved a Nobel Prize for it.

