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The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine
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The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine

3.45  ·  Rating details ·  171 ratings  ·  30 reviews
In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and ...more
Hardcover, 352 pages
Published September 7th 2010 by Free Press
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3.45  · 
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 ·  171 ratings  ·  30 reviews

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BAM The Bibliomaniac
This was persuasion pure and simple. Get screened for a genome profile. It's only tens of thousand of dollars. But companies are striving to produce a profile at reduced cost-hence the $1,000 genome.
What will this unleash in society? It's possible to locate genes from anything from quick twitching, obesity, to cancer. Will employers deny employment because of a possible condition? Will married couples screen fetuses for defects or neural disease? Will prospective in laws screen a potential fian
Jun 29, 2011 rated it really liked it  ·  review of another edition
Interesting history of gene sequencing and the trends towards faster cheaper full genome sequencing. Of course the question is now what? Apart from providing an interesting history of the human species, how do we use this knowledge to make life better? Lots of opportunities, but still a technology searching for a problem to solve. Somehow this will be useful in helping target medicines to appropriate patients.
Subin Sahu
Dec 02, 2018 rated it it was amazing
The topic of the book is relevant to my own work, so I was primed to have to be drawn to this book. The book didn't disappoint at all; both the technical descriptions of sequencing technology and discussions about their socio-economic impacts were well presented in the book. Since DNA sequencing is a multidisciplinary technology, people with interest in different scientific discipline will find this book interesting. For others who are not particularly interested in science, the book covers inte ...more
Aug 21, 2017 rated it really liked it  ·  review of another edition
4.5 stars.

This book made for fantastic listening, but I think only because I work in a related field in which we use DNA sequencing as a tool to identify parasites. I was already familiar with the words 'Illumina platform', '454', 'Big Dye', 'ABI', 'PacBio', 'IonTorrent', 'Nature Genetics' etc before I read the book. But if you don't know what those words mean, parts of the book could make for a pretty boring read, or may seem to have too many technical details.

The effort of the author in prese
Blablabla Aleatório
Mar 12, 2013 rated it really liked it
Shelves: nubia
Nem lembro direito de como decidi que queria ser bióloga, mas me recordo que os meus interesses na Biologia sempre variaram muito ao longo do tempo. Quando estava no ensino médio, por exemplo, eu queria muito ser geneticista. Eu até falava que ia fazer meu mestrado com a Mayana Zats na USP… Passou o tempo e acabei me enveredando por outros caminhos, mas a admiração e curiosidade pelo mundo da genômica nunca passou, e sempre que fico sabendo sobre um livro de divulgação científica (uma das minhas ...more
Dominick Lemas
Dec 25, 2011 rated it really liked it
Shelves: genomics
Kevin Davie's- The $1000 Genome- was a great read and one that I would recommend to the growing majority of people who want to learn more about DNA technologies that will inform personalized medicine. This book does a good job in balancing the "promise" of genomic medicine with the current limitation and future challenges. Several billion dollars in tax payer $$ have been spent subsequent to the 2.7 billion dollars and 13 years that were required for the Human Genome Project. This book attempt t ...more
A good solid nontechnical introduction to the world of genome sequencing, and what revolutions may await humanity when we can all access our genetic information cheaply and effectively. Davies does a great job of capturing the personalities involved in this rising industry, describing both warm personalities and angry CEOs (I'm looking at you Keri Stefansson). Davies primary conclusion is that genomic sequencing technology is quickly evolving, and indeed, we may already have devices that can seq ...more
Dec 09, 2010 rated it liked it
this is a co-review of "the 1000 genome" (2010) and "cracking the genome" (2000), two of kevin davies' popular texts. i was reading these concurrently, kind of hopping back and forth, and it was an interesting way to do it. in "cracking the genome," he's tracing the history of the human genome project, culminating in a 2001 initial draft sequence. and the promise to revolutionize medicine. then, "1000 genome" chronicles the rise of DTC testing and falling costs of genetic technology (genotyping ...more
I took a microbio class this past semester, and my professor had worked (well, interned) on the HGP. He spent a good bit of time talking about personalized medicine and the future of DNA sequencing, which I found pretty interesting. (I'm mostly interested in the practical applications in the clinical setting, given that I'm going into medicine.) Hence me spending my semester break hitting up the library for some books on the genome.

I felt that this book was well-written, and had a nice, conversa
Jan 17, 2014 rated it liked it
Shelves: nonfict-science
A decent intro to the $1,000 genome -- a bit about the science and the bioethics and the implications of a $1,000 genome, mixed in with *plenty* (a bit too much, IMHO) about the "business" side of things. The book is mostly structured around the people involved: the initial pioneers, company founders, early adopters; their ideas, their plans, their regulatory and financial battles, etc. The chapters were relatively disconnected from one another, which didn't bother me much. Unfortunately, just 3 ...more
Gary  Beauregard Bottomley
The author lays out the recent history of personal genomic testing and what to currently expect. Most of what is learned by testing won't be actionable, some of the rest will be to eat more broccoli, and the remainder will be told to eat even more broccoli and to exercise. We already know that even before taking the test.

The author does cover the material very well, and most importantly makes the topic relevant to the reader. The topic is exciting more because of what could be than what is. The
Mar 27, 2011 rated it liked it
Davies provides a comprehensive overview of the several businesses that are vying to take a lead in this upcoming field. He moves along nicely when talking about far reaching policy implications to health insurance, preventative medicine and orphan diseases. Just like DNA exons and introns though, not everything in this book had to make the cut.

In a scientific paper the "Methods" section is important, but in this format I prefer a more concise summary without as much jargon. I recognize that th
Sep 20, 2015 rated it really liked it
Might this be a life-changing book? Its listening comes at a time when I contemplate going to say "Goodbye" to my brother in the end stages of pancreatic cancer. It causes me to wonder whether knowing his genetic code several year ago might have given rise to treatments for him that might have given him a fuller number of days. Certainly there are elements of hype to the term revolution - after all, knowing you are likely to have Alzheimer's is of little value, today. But certainly in years to c ...more
An excellent intro to the current state of DNA sequencing, the personalities behind some of the leading companies and technologies in the field and the ethical and cultural issues implicated by personal genomics.

DNA sequencing is evolving so quickly that the description of the industry is already a bit out of date. Davies must have started on this in 2007 or earlier.

That said, it would probably be impossible to write a book that wouldn't seem a little dated by the time of publication.
Ian Bradbury
Apr 13, 2014 rated it really liked it
I quickly read through this book, it kept me absorbed throughout. Its a really interesting subject, and one of those books that has a very limited shelf-life - it covers a subject that is moving very, very quickly. In fact it is already out of date but still worth reading as it gives good pointers on where things are heading. If you have any interest on what genetics will mean to medicine in the near future, this is a must read.
Bob Buchan
Jan 08, 2011 rated it it was ok
Shelves: science
"Very interesting topic, disappointing book. Davies' focuses more on the commercial implications for genetics and the companies and leaders in the field, rather than explaining what's happening to amateurs interested in the field. One can't help but being impressed by the speed of development in this area of science."
Kevin's a great guy and I've worked in the field long enough that this was a must-read. I enjoyed the personal anecdotes and quips from those in the field that we love and, well, don't love as well. Lots of good stuff in here though the chapter order seemed a bit odd to me. Definitely a worthwhile read and a fairly quick one as well. A great inflight book!
Apr 17, 2016 rated it liked it
Shelves: nonfiction, science
Pretty good. It definitely does a good job of giving you an overview of what's going on in the world of personal genomics and how the price of sequencing is dropping. However, it doesn't do a spectacular job of presenting facts in a way that gets them to stick in your head. Still, if you're interested in the topic, it's worth reading.
Jan 18, 2012 rated it it was ok
Chronologically confusing, it jumps from one genetic company to the next with ever page and, to add to the confusion, it goes forward and backward in time - spewing names at you faster than you can say Deoxyribose. Not to mention that, instead of wasting hours reading this book, you could simply look up the progress of genetics online - it'd save you time and trouble and confusion.
Sep 02, 2012 rated it it was ok
Shelves: genetics-related
good overview of history of sequencing industry.. at least I think/trust that it was. but also a slog to get through and written in a way where I'm not going to remember the companies or dates; it's all just jumbled in my head.
Joanne  Manaster
Jan 20, 2011 rated it really liked it
Very good for giving the overview of the BioTech industry as it applies to the Human Genome sequencing race and the potential for use of this information in the future for Personalized Medicine. Wish it had more details on the next gen sequencing technologies.
Michael Gross
Nov 08, 2010 rated it really liked it
A very topical account of the ongoing revolution in genetics and genomics.
Mar 30, 2013 rated it really liked it
A good discussion of sequencing technologies and their applications. Focus on the commercial and medical side.
Apr 20, 2016 rated it it was amazing
Shelves: science
[In 2007 Craig Venter's and James Watson's genomes were sequenced.
23andMe thought about social platform like Facebook to share genetic code.
DeCODEme - WuXiPharmaTech.
Sarah Lees-miller
Mar 04, 2014 rated it liked it
The first half of the book is really very interesting but it gets very slow later on.
Sep 28, 2016 rated it liked it
Shelves: genetics, science
Jan 20, 2015 rated it it was ok
Amazing information but getting too technical for me. I didn't realize the enormous impact hat the genome has on civilization and what is coming in the future.
Jan 16, 2011 rated it did not like it
Shelves: abandonned
This was a rather boring book. I wouldn't recommend you read it unless you had to.
Ashley Chen
Nov 08, 2013 marked it as to-read
Another rec from a biopharm prof XD
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Born and raised in London, Kevin Davies studied at Oxford University and moved to the U.S. in 1987 after earning his PhD in genetics. He endured two years at the bench before seeking refuge in the editorial office of Nature magazine. He was the founding editor of the journal Nature Genetics and has also worked at Cell Press and the Howard Hughes Medical Institute. He is currently the editor of Bio ...more