Organic Synthesis: The Disconnection Approach

by Stuart Warren, Paul Wyatt

One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This "disconnection" approach to synthesis is now a fundamental part of every organic synthesis course. "Organic Synthesis: The Disconnection Approach, 2nd Edition" introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.

Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.

This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, "Organic Synthesis: Strategy and Control."

Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.

"Organic Synthesis: The Disconnection Approach, 2nd edition" provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

Genres: Chemistry, Science, Reference, Nonfiction

346 pages, Paperback

First published February 1, 1984

Reviews

[Samane Lou]

کتاب بسیار مناسب برای راهنمای سنتز ترکیبات شیمیایی، برای کنکور ارشد و دکتری شیمی عالیه، همینطور برای آزمون جامع دکتری...برای بار چهارم خوندمش و بازم مطمئنا میام سراغش.
همین.

[Zsolt Fazekas]

A great way to learn the retrosynthetic method for organic chemistry. Entertaining, clear, straightforward. Also a great way of practicing for upcoming chemistry exams ;) It also strengthened my belief that organic chemistry is basically (mostly, but not only) about the two following rules;
1) the easier to understand "positive centers go to negative centers"
2) the harder to understand (but maybe a bit less common) "HOMO goes to LUMO"
I have fellow students who struggle with orgchem and I always say this to them and usually they just wave and do not believe me. :D
Anyway, it was worth buying and reading. Recommended.

[Charlie Pearce]

A thrilling holiday read for the beach!

[Roland Lacroix]

The student's bible to retrosynthesis, via the disconnection approach (recommended by my lecturer). The true test will be my exam results.

Edit: Managed to pass, a solid victory imo.