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The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines
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The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines

4.12  ·  Rating details ·  101 ratings  ·  17 reviews
Developing life-changing drugs is risky and expensive—but that’s not what makes them unaffordable.

Drug pricing is a staple of every news cycle and political debate. And while we’ve struggled for decades to agree on solutions that serve all patients without jeopardizing the invention of new medicines, many Americans suffer because they can’t afford the drugs they need.

D
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Kindle Edition, 269 pages
Published January 17th 2020 by Evelexa Press
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Richard Zhu
Jun 28, 2020 rated it it was amazing
If anyone asks you why drug prices are so expensive, you respond with, "Not really" and you give them this book. Some takeaways:

- The drug industry as a whole does not make exorbitant profits. With profit margins from 10-20%, it has lower margins than banks/software and more in line with those of oil/gas.
- Most complaints about drug pricing comes from "branded" drugs, which are under patent and sold exclusively by the drug company that brought it to market. The way to think about these is that t
...more
Anne Rolim
Nov 01, 2020 rated it really liked it
Quite an insightful look into the pharma & biotech US and global markets. Absolutely recommend for anyone interested or affected by the theme. Much of it I was not aware of and came out of with much more knowledge on drug pricing & development than I had previously.
I believe it could have been more concise as I saw repetitive themes being brought on (to be fair, they might have been put there to bring home the argument - but unfortunately made it a longer read). Nevertheless, the author’s propo
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Jonas
Jul 25, 2020 rated it liked it
How do you make drugs more accessible and affordable while still maintaining incentives for innovation? Peter Kolchinsky, a scientist and biotechnology investor, argues that governments, pharmacy benefit managers, and insurance companies must shift the burden of funding innovation away from consumers (through onerous co-pays and selective reimbursement of generics and specific drugs) and allow pharma companies to reap the profits in the marketplace. To balance this, he argues that novel drugs, t ...more
Manik Patil
Nov 12, 2020 rated it it was amazing
A serious, compelling and informed call for change.

The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines is an examination of prescription drug pricing in the United States.

Authoritative: Peter Kolchinsky, PhD, is a biotechnology investor, scientist, and passionate about this topic. He co-founded and runs the Boston-based investment firm RA Capital Management. Peter wrote this book because he wanted to defend his industry against the facile and disingenuous a
...more
Vidya
Jul 26, 2020 rated it really liked it
This was a timely read given the executive orders passed last week. I’m still turning this over in my mind, but think the logic of the arguments presented here are sound. The key takeaways and insights are the following. First, branded drugs are a very small portion of overall healthcare spend yet draw a huge amount of ire - this does not make sense. Additionally, drugs are the only part of healthcare that structurally decrease in cost over time through genericization. Second, the key argument f ...more
Kevin Luo
Nov 09, 2020 rated it it was amazing
Drug pricing is a huge talking point between the pharmaceutical/biotechnology industry, politicians, citizens, and people. It is often an extremely controversial topic and extremely nuanced due to the challenges of understanding the US healthcare system which is unbelievably convoluted and complex. Peter Kolchinsky in this book discusses the benefit of the biotechnology industries, justifies drug pricing, and gives rationale as to why this is so. He discusses that innovation is for the benefit o ...more
Courtney Smith
Jul 14, 2020 rated it liked it
An interesting take on the issue of drug pricing. This book points out the under appreciated benefit the pharmaceutical industry in the form of generic drugs, that can be used by anyone for cheap. What is the cost to society? Investing into the brand name version of drugs while they are patent protected, similar to paying a mortgage to eventually own your home. This is different from other health care costs (like diagnostics procedures or surgery), which will continue to increase over time. The ...more
Gunnar Esiason
Jun 16, 2020 rated it it was amazing  ·  review of another edition
I can confidently say The Great American Drug Deal is one of the better healthcare books I have read in a long time. Easier to understand than ‘The Antidote’ and far more engaging than ‘Superbugs,’ The Great American Drug Deal is an in depth look at the inner workings, shortcomings and successes of the American healthcare industry. Kolchinsky’s thesis that generics pay lasting dividends to society at the cost of branded drugs is one worth deeply considering. He defends the biotech industry, but ...more
Jeff Heuer
Apr 20, 2020 rated it liked it
I learned a good amount about new drug development and pharmaceutical market structure and mechanics from this book. It could stand to be quite a bit shorter and still make its key points well. The book is, transparently, a defense of pharma profits by a biotech investor, and critique of health insurer efforts to constrain those costs. I’d be interested to hear an insurance industry or public health policy response.
Brendan Conley
Apr 28, 2021 rated it really liked it
Mostly well written book with great information pertaining to health insurance and PBM’s in America. Definitely a bias toward the pharmaceutical industry, where you can tell he defends them more than he should, seeing as he’s an investor and active member of the industry. Good information in here, but keep an eye out for the bias
Ian
Mar 27, 2021 rated it really liked it
Thought provoking book that explores many of the economic incentives pharmaceutical companies and the US faces. Good read for anyone looking for a simple yet comprehensive overview of consequences that result in the pharmaceutical industry from us healthcare system and a way to address them.
Samantha Michele
Mar 21, 2021 rated it it was amazing
Interesting, compelling, well-researched book that challenged a lot of the overly-simplified views I had on the drug industry.
Anjali Lal
Apr 01, 2021 rated it it was amazing
Absolutely brilliant.

It is the story of affordable medicine in US.
Detailed, nuanced, scientific, thorough and yet never boring.
Adam Agonis
Apr 09, 2021 rated it it was amazing
A persuasive argument in favor of drug patents and better insurance coverage for all medically necessary procedures.
Andrew Brown
Feb 24, 2021 rated it it was ok
Most biased book I’ve ever read
Adam
Apr 10, 2021 rated it it was amazing
A persuasive argument that drug patents are justified but insurance is the real culprit behind Americans' inability to provide affordable prescription drugs. ...more
Nagarjun Chakilam
Apr 07, 2021 rated it really liked it
Peter nicely presents thought-provoking ideas on why drug prices are higher (or not) and how drugs can be made affordable. All his arguments are well supported by strong examples.

If you don't have time, just read the last chapter which sums up very well the main ideas the author wants readers to takeaway.
...more
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