Cain left everything he knew behind after his tortuous father, the man who enacted horrible experiments upon young Cain to try and give him the Pure Sight, finally passed away after Cain turned 17. For six years following he found himself at AFresh, a mental hospital where the Voice and the Face worked tirelessly to try and fix him damaged mind. The mind where the Siren sounds and the Shadow followed, is where he finally discovers just how troubled he was. After waiting all those years, AFresh deemed him free, allowing him to move into a small apartment, one where the landlord Peter warned him to not dig into the other tenants personal lives, because everyone of them had a secret to hide.
From Magenta, a woman who shape shifts into another person everyday, who turns out to be the Mother who has been absent for all of Cain's life, not even a trace of her to be found in the broken house he shared with his father. Leading into George, a troubled man who turns into a dog to hunt and kill people to feed an insatiable hunger. To Sister Josephine, a woman who possessed the ability to fly, and used her shocking good looks to lure men in to literally fuck to death through rape. This leaves Cain to witness the Whistler, an older man who played him pipes, leaving a room full of followers, animals permanently with their head cocked listening to something, even a woman left frozen, looking stuffed and stages on a rocking chair for years. After witnessing death since his arrival, Peter comes to him with information on his Father and the other Tenants, which enraged George, causing him to viciously murder Peter after shifting. As everything falls apart, Cain uses the powers of the Shadow to help murder George after he murdered a little girl and her family in a bid of power to Cain. All of those tenants, cursed with the evil of Pure Sight.
As Magenta shows him what was hidden behind Peter's house marked Heaven, the skulls of deceased Pure Sight individuals, many skulls deformed by their abnormalities and powers. As Magenta turns to leave, Cain discovers no one can see him anymore, because he is now one with the shadow. Returning back to Apartment 13, he sees those left, the tenants who all say one fleeting word without realizing Cain was listening in. "I hope I see him again." Now understanding finally dawned on Cain, leaving his with the knowledge fo so many deaths, including the man who possessed him apartment he holds now, a Man named Vlad, crippled in the circus years ago and left wheel chair bound.