This book on SciELO has been prepared with the same sentiment – to document the best practice of Open Access Publication. It is the first case study of this kind, which appreciates and documents the positive contribution of SciELO. SciELO Network websites hits of over 1.0 million per day to explore sciences, and a similar number of downloads of scientific research are not mere numbers! It’s a testimony that SciELO has been a beacon to spread and expand knowledge contained in pages of journals and books. From the launching of 10 journals at a public workshop in São Paulo in 1998 to the current level of over 950 journals and near 500,000 freely downloadable articles is a remarkable feat and an example of Open Access approach par-excellence!