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Still Down: What to Do When Antidepressants Fail

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Major depressive disorder is a common medical condition that can be disabling and can persist for months, even years. Many people experience depression symptoms that resist treatment. Although they try various combinations of medications, psychotherapy, or electroconvulsive therapy, their symptoms don't improve. What can people who have treatment-resistant depression do to overcome their depression and feel better?

In Still Down, Dr. Dean F. MacKinnon, a psychiatrist at Johns Hopkins Medical School, presents nine composite stories drawn from patients he has seen in his twenty years as an expert in treatment-resistant mood disorders. The first section of the book features people diagnosed with depression who have not yet received appropriate treatment. The next section looks at misdiagnosis, focusing on people who feel and appear depressed but who have different mood disorders and need treatment for them. Finally, Dr. MacKinnon describes people who have severe depression that does not respond to any treatment, regardless of how finely tuned the treatment might be. These people, who suffer from true treatment-resistant depression (TRD), can benefit from a variety of treatments to feel better.

Dr. MacKinnon provides commentary to explain and extend the discussion of the patients and situations in each case. He also discusses common obstacles to improvement, including overly conservative dosing, problems stemming from not adhering to treatment, antidepressant failure, and high sensitivity to side effects. By identifying aspects of the individual's qualities, behaviors, and experiences that may account for poor response to treatment, Still Down points the way for people with TRD and their families to find appropriate diagnoses and the best possible care.

152 pages, Paperback

Published November 15, 2016

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Dean F. MacKinnon

3 books2 followers

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5 stars
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Displaying 1 - 4 of 4 reviews
889 reviews24 followers
November 21, 2016
No actual advice on what to do if antidepressants don't work except more antidepressants. Case studies are interesting but still assume depression is the main issue. No real interest in looking at other causes or diseases.
Profile Image for Crystal.
37 reviews1 follower
January 7, 2018
A very misleading subtitle, this book does not offer options for what to do when anti -depressants fail. Instead, it just offers various stories about patients dealing with depression symptoms. I wouldn't recommend this book to anyone trying to get help for their own depression problems.
Profile Image for Masont1999.
68 reviews
May 3, 2022
2.5 stars but I'll round up bc the book is more than well meaning. Don't regret giving it a try, by any means
Profile Image for Tracey Gill.
53 reviews3 followers
December 30, 2016
Misleading title. It is a series of case studies focusing on drugs.
Displaying 1 - 4 of 4 reviews