Magneto plays the more prominent role in this issue as he continues to play a role of neutrality, avoiding an outright alliance with Xavier and the Avengers, but also showing reticence in working with Doom. Meanwhile Reed frets about Sue who is out in the midst of Battleworld fighting, and is doing so while being quite pregnant. Notably, this issue is the first appearance of Titania (and the more minor recurring villain, Volcana) who adds to the villains cause in fighting against the heroes.
A lot is packed in here, but the series is already repetitive by the third issue.