First of all, Adam Warren is the man.
Secondly, you don't have to know a thing about Gen 13 to enjoy this book.
And, it's aged great! It's from the mid 90's but still seems so fresh to me (despite the numerous 90's pop culture references).
Need more reasons to check it out? The art is a wonderful mash-up of anime style and American superhero comics. The storytelling and dialogue is hilarious and spot-on. If you can find a copy, by all means read it.