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Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime

4.07  ·  Rating details ·  715 ratings  ·  78 reviews
      A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
      Nearly all scientists who study the biology of
Hardcover, 400 pages
Published September 4th 2007 by St. Martin's Press (first published 2007)
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Pablo Hahaha, in his Ted Talk, someone asked him why he looked like an old man when he was selling the idea of being young forever... he said he was actuall…moreHahaha, in his Ted Talk, someone asked him why he looked like an old man when he was selling the idea of being young forever... he said he was actually hundred of years old.(less)
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Tj Murphy
Jan 25, 2009 rated it it was amazing  ·  review of another edition
Shelves: science
I had been wondering about the legitimacy of the idea of radical life extension, and was lead to this book. De Gray is a gerontologist - he does basic research into the causes of aging related diseases - and his stated purpose in writing this book is to encourage the public to view aging as a treatable disease rather than an inevitable part of the cycle of life and death.

The book consists of a short moral argument about the immediate importance of researching aging (because it maims and kills h
May 11, 2011 rated it really liked it  ·  review of another edition
The science is fascinating, but de Grey's ego can be a distraction. ...more
Karel Baloun
Apr 13, 2017 rated it really liked it  ·  review of another edition
Aubrey de Grey provides an optimistic service in summarizing all aging into seven general physiological areas, and providing a framework for science-based rejuvenation: strategies for engineering negligible senescence (SENS). Each area includes rather detailed biochemical and physiological explanations, and an evaluation of progress from related medical work.

The 7 areas are:
Mitochondrial DNA failures
Cell loss/atrophy, incl Immune senescence
Death avoiding cells
Intercellular junk, and lysos
Live Forever or Die Trying
Oldie but a goodie. A must-read introductory text for those interested in longevity sciences.

The book is broken down into three parts.
1. A moral argument as to why aging should be the highest disease on our hit-list
2. An explaining of SENS and a detailed biological explanation on how we think we can combat these aspects of aging
3. A rallying closure that urges you to take part.

For me the moral argument of this book is the lynch pin for new readers on the topic of longevity.

Other reviews of this
Zarathustra Goertzel
=D The book describes many various forms of aging and strategies to clean them out or obviate them. I've never really had a biology class, so I found it to be a good primer in that sense too. I've wanted to live forever since I was a kid and never doubted its possibility. So it's very nice to have a general view of how we may actually do this.

One can tell which chapters De Grey knows more about and which he doesn't. The ones he knows the best are far better written.
Bo Blanckenburg
"Give me all your pension money, and I'll make sure you live forever!" Yeah, like we hadn't heard that one before. It's written in a fun way, but as a moleculair biologist I was cringing every other page at inconsistenties and misquotations to plain basic science. Would work as a fictional book, not a scientific one. Have a good laugh, and forget about it. ...more
I am happy that someone or some people dare to explore this domain. That left me hopeful and excited....
Jan 01, 2010 rated it really liked it  ·  review of another edition
read the book, become obsessed with living forever
I've been wanting to read this book ever since I saw a youtube of the Aubrey de Grey giving a Google authors talk (There's also a fairly good, much shorter TED talk - well, by now, I think there are several). So, I finally did. The book is now 12 years old, and I can't seem to find a video that I'm sure was the original (I know it was at least an hour long, and at the end someone asked a question, "If your goal is to become young, why do you assume the appearance of a very old man?" To which he ...more
Omar Delawar
Jul 03, 2021 rated it did not like it  ·  review of another edition
Aubrey de Grey is the biggest crackpot to ever exist. If you do not believe this review, look him up on google - there is a documentary where his lies are exposed. He is not even a PhD and has only set foot in an institution of higher learning as a school administrator/clerk, not faculty. In this book he presents pseudo-scientific, highly speculative theories which have been proven to be completely impractical and downright impossible scientifically by experts in the field. Here, I'll save you a ...more
Masatoshi Nishimura
Mar 16, 2019 rated it it was amazing  ·  review of another edition
Shelves: science
I appreciate Aubrey took the time to write this book. It was meant for a layman. And I know how hard it is to translate scientific knowledge to someone with not-so-science background people. He starts each chapter with interesting metaphors like grilled Turkey on Thanks Giving and our aging. That kept my interest high in the pile of technical jargon.

I also like how Aubrey writes down how he has approached a problem and his thinking process. Obviously, he's an intelligent man. But that type of t
Harry Harman
kindling the sparks that we must fan into a blaze that will cast out its obscuring darkness and melt its frozen grip."

maybe I should have—but there's a trade-off

I've been spending every waking hour

There are mutations in our chromosomes, of course, which cause cancer. There is glycation, the warping of proteins by glucose. There are the various kinds of junk that accumulate outside the cell ("extracellular aggregates"): beta-amyloid, the lesser-known transthyretin, and possibly other substances
Scott Lerch
My gut feeling is this book is overly optimistic about how easily aging will be overcome in the near future, but as Ray Kurzweil would say human intuition is really bad when it comes to scientific/technological progress. The premise sounds good: don’t try to fix the all the complex metabolic pathways that contribute to aging, that’s near impossible, instead just try to clean up all the toxins and junk that builds up with age, and we will stay youthful. Of course it’s a little more complex than t ...more
This was a good book, but beware: It is probably too technical for the layperson.
Aubrey de Grey believes that aging can be defeated. In the book, he describes aging as an inevitable side-effect of our biological processes and metabolic pathways. That we accumulate "damage" from the normal operation of our bodily processes.
He makes the case that we can overcome aging with biological "maintenance". He uses the analogy that hundred year old cars are still operational, if they have been maintained
Jun 25, 2008 rated it really liked it  ·  review of another edition
The only certainty is taxes, apparently.

Throughout human history, we have accepted the life of our parents as a template for our own lives. In concious ways, but also in unconcious ways. Like the inevitability of death. But we will be forced to re-evaluate even that, it seems.

This chatty british author fires the first shot over the bow. There will be better authors to cover the subject (Gladwell? Please?), but DeGrey got here first. And he's maybe a bit condescending in how he 'exposes' our "pro
Mohamad Ahmad
Jan 19, 2021 rated it really liked it  ·  review of another edition
Aubrey De Grey is on a mission to break the spell that pervaded our culture: the pro-aging trance. Over the millenias, a lot of attempts to reach immortality and prolong lives have failed and it has been percolating through the generations the notion that Death is inevitable and part of life and there is just nothing that can be done about it. We should strive to make the most of the few "meaningful" decades we have on this earth and that is that.
The author begs to differ, and he wrote an entire
Jan 01, 2017 rated it really liked it  ·  review of another edition
Inspiring read, I've read a few articles about separate concerns mentioned throughout the book, but most of all I couldn't help but circle back on the implications of a significant extension of life and what that would mean for our species here on earth (and/or elsewhere) ...more
Sep 18, 2011 rated it really liked it  ·  review of another edition
Amazing. The book gets technical at times for light reading, but I appreciate the confidence. Some very exciting ideas in this book!
Jun 29, 2018 rated it did not like it  ·  review of another edition
Shelves: waste-not-for-me
DNF. Author has a serious case of egocentrism
Mar 30, 2018 rated it liked it  ·  review of another edition
Shelves: science
I had read a few articles about de Grey before starting the book so I knew his basic ideas:

-Aging is an engineering problem.
-We need to fund research on "fixing" aging, not just "understanding" it.

Turns out I really didn't learn too much from the book.

First, I didn't find it very well written for a science book for the general public. He sounded far too defensive and querulous. Most importantly his ideas didn't flow smoothly.

Secondly, it was FAAR too dense with detailed biochemistry. I don't thi
Apr 10, 2019 rated it it was amazing  ·  review of another edition
This book changed the way I view aging, from something inevitable (which to be fair it always has been), to something that is an engineering challenge to be fixed.

It's not just about increasing lifespan, it's about maintaining your health as you age (healthspan).

The beginning and end of the book explain the psychology, biology and rationale for the approach to end aging.

The middle goes deep into some of the science around the 7 areas of accumulative aging damage to tackle. You can probably skip
Jul 28, 2019 rated it it was amazing  ·  review of another edition
Absolutely brilliant!

My highlights:

Mitochondrial Theory of Aging explains a big deal, but it doesn't work by gradually accumulating damage in the mtDNA.

Mitochondia produce a vast amount of ROS for our metabolic purposes which damage:
1. The mtDNA
2. The mitochondrion's membrane

If the mitochondrion's membrane is damaged, the lysosomes will detect this damage and just get rid of it. But if only the mtDNA is damaged without damaging the membrane, the lysosomes will fail to detect and recycle this f
Oren Milman
Aug 06, 2021 rated it it was amazing  ·  review of another edition
Shelves: favorites
Easily 5/5 stars. One of my all-time favorites.

This book is extremely informative, and the writing and writing style are great, with numerous delightful helpful analogies to explain the biology.
I don't know how well it would fit people with different backgrounds in biology, but it was pretty much perfect for me at this time.

There is a relatively short section that discusses science-politics instead of the science itself, but the rest of the book easily makes up for that. Also, I suspect the sect
Jul 23, 2017 rated it liked it  ·  review of another edition
Shelves: science
Certainly an interesting and consequential subject matter, "Ending Aging" catalogues the many aspects of aging on the cellular level, discussing strategies toward remedying the process, as well as the current state of scientific progress on those fronts. The polemics arguing for why the pursuit of ending aging is a good thing in the first place - something that I, along with de Gray, see as an unfortunate distraction to this issue - are well done. There were however long stretches of what seemed ...more
Wojciech Andreas Jurczyk
A joy to read! Ageing is first demystified, then divided into several facets. Lastly, it's not conquered, but de Grey (and his co-author) describes in detail many strategies how to get there. He touches not only on the biological/physical problems of defeating ageing, but also addresses the moral, political, and economical hurdles.

What you won't get from this read is a projection of how life will be like when everybody gets into their four digits and more (= science fiction). But to be fair, th
Sep 09, 2019 rated it it was amazing  ·  review of another edition
I'm having trouble rating this book. I don't have the knowledge to evaluate the information provided as most of the biology and chemistry is well above my head. I decided to give it the rare 5 stars because I can't think of many or even any subjects more important than the one in this book. I wish everyone will read it and get infected with Aubrey de Grey's enthusiasm for a better future.

About the book itself, I had a "holly shit!" moment when he described that one scientist didn't want to be as
Justin Norman
Jul 24, 2020 rated it it was amazing  ·  review of another edition
A fascinating look at several methods of life-lengthening and death-defeating research. A lot of the details about the intricate processes in this book went over my head, but the majority of it was very interesting. As someone who isn't at all knowledgeable in this field, it's impossible for me to say whether he makes a legitimate case for his methods' effectiveness or not, but it's encouraging that someone is trying to tackle the biggest health problem of all — one that doesn't even seem to occ ...more
Feb 17, 2021 rated it liked it  ·  review of another edition
Really informative read for me as a non specialist and someone curious in cures for aging (yes, I think aging is terrible and a disease). However, I spent most of the time on Wikipedia and Khan academy trying to understand what's going on and I wouldn't consider myself an incompetent learner. Overall, new research and medical methods are good to know but it would be great if it were delivered in a more digestible fashion. 2 stars deducted for writing style and for being loaded with domain specif ...more
Teo 2050


de Grey A & Rae M (2007) (16:04) Ending Aging - The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime


Part I

01. The Eureka Moment

02. Wake Up—Aging Kills!
• Why Did I Write This Book?
• The Motivation for the Pro-Aging Trance
• A Word About SENS Skepticism
• Building a Case, Chapter by Chapter

03. Demystifying Aging
• The Illusory Boundary Between Aging and Disease
• Why Aging Doesn’t Need a Timer
• The Corollary That Even Most Experts Overlook
Brian Yap
Jun 18, 2018 rated it it was amazing  ·  review of another edition
Metabolic processes in our bodies are merely chemical reactions. The aging phenomenon is caused by the accumulation of damage to biological structures and the induced state of dysfunctional cells. Strategies to reverse such damage on a cellular level are plausible and such efforts deserve more research funding and awareness. A great introductory book for anyone seeking answers to a scientifically possible equivalent of the Fountain of Youth.
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“I have been aware for many years that most people do not think about aging in the same way that they think about cancer, or diabetes, or heart disease. They are strongly in favor of the absolute elimination of such diseases as soon as possible, but the idea of eliminating aging—maintaining truly youthful physical and mental function indefinitely—evokes an avalanche of fears and reservations. Yet, in the sense that matters most, aging is just like smoking: It’s really bad for you.” 1 likes
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