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The Immune System
by Peter Parham
The Immune System, Second Edition has been designed for use in immunology courses for undergraduate, medical, dental, and pharmacy students. This class-tested and successful textbook synthesizes the established facts of immunology into a comprehensible, coherent, and up-to-date account of how the immune system works, rather than presenting immunology as a chronology of exp ...more
Published May 25th 2004 by Garland Science
(first published December 1st 1999)
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Rough for the first timer, but the more comfortable you become with immunology, the more comfortable you become with this book. I ordered it to fill in the gaps of our 'assigned' text in my immunology course. I loved it. Spent more time on making the details clear, which I appreciated. However, I could see how - if you're looking for a cliff notes version of immunology - this just wouldn't be your cup of tea. Only serious educators, and life-long learners need apply. I still pick it up from time ...more
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“Unlike some other immune-system gene families, whose genes are all clustered together on one chromosome, the 10 human TLR genes are distributed between five chromosomes. This reflects the ancient, invertebrate origin of the Toll-like receptors, which were present before the two genome-wide duplications that occurred during the early evolution of the vertebrates around 500 million years ago. On the basis of sequence similarities, the Toll-like receptors form four evolutionary lineages (I, II, III, and IV) that are descendants of the four Toll-like receptor loci formed by these two ancient genome duplications.”More quotes…