Jeffrey Dach's Blog, page 6
February 28, 2024
The Dangers of Non-Hormonal Menopause Drugs
The Dangers of Non-Hormonal Menopause Drugs by Jeffrey Dach MD
Mary is a 55 year old breast cancer survivor. Her breast cancer was diagnosed at age 47 and treated with lumpectomy alone with no recurrence after 8 years of follow up. Recently, Mary has been experiencing menopausal symptoms of night sweats and hot flashes, so she asked her primary care doctor about hormone replacement. Since she has a history of breast cancer, her primary care doctor suggested Mary take a new non-hormonal drug called Veozah for relief of the night sweats and hot flashes. Mary started the drug and thankfully, the night sweats and hot flashes resolved. Header image: Dr. Felice Gersh, courtesy of Felice Gersh MD and Karen Martel.
Brisdell, SSRI Antidepressant Called Paxil
The first FDA approved non-hormonal treatment for nigh sweats and hot flashes was Brisdelle, an old drug FDA approved 10 years ago in 2013. Brisdelle is an SSRI antidepressant called Paxil. All SSRI antidepressants are medically ineffective for menopausal symptoms of hot flashes. That is why Paxil never caught on for treatment of hot flashes. This was discussed in my previous 2013 newsletter entitled, FDA Approval for Paxil for Hot Flashes A Cruel Joke ?.
Adverse effects of Paxil and all SSRI antidepressants include sexual dysfunction, emotional blunting, and increased risk for suicide, homicide and violent behavior. SSRI drugs are addictive and discontinuation carries side effects, so they must be tapered gradually under supervision. Needless to say, this is not good, and this was all discussed in my previous article: The SSRI Antidepressant Hoax.
The New Drug is Veozah
The new non-hormonal drug is called Veozah (fezolinetant), FDA approved a year ago in May 2023 for the treatment of menopausal night sweats and hot flashes. Unlike the failed Brisdelle SSRI antidepressant drug, Veozah actually DOES WORK ! The drug successfully reduces hot flash symptoms by blocking the Neurokinin3 receptors (NK3r) in the brain. The NK3 receptors are the neuron receptors in the hypothalamus that radiate to the autonomic centers controlling thermoregulation. A 12 week study showed Veozah efficacy for reduction of Hot Flashes is about the same as estrogen hormone replacement. This study was funded by Astella Pharaceuticals and was extended for a 40 week blinded observation period, so the entire study lasted one year. (1-2)
Gastrointestinal Adverse Effects
Neurokinin 3 receptors are also found in the gastrointestinal tract, expressed in efferent fibers of the vagus nerve which innervate parasympathetic nervous system of the GI tract, thus accounting for the gastrointestinal side effects of abdominal pain and diarrhea reported in the clinical trials for Veozah.(1-2)
In 2002, Dr. C. Blondeau writes:
neurokinin-1 and neurokinin-3 receptors are involved in the parasympathetic control of digestive functions.(3)
Neurokinin 3 receptors have also been implicated in various auto-immune diseases. Whether or not Veozah will increase auto-immune disease remains unknown. Our knowledge of neurokinin receptors is still in its infancy, and it may take years of research to uncover the adverse effects of blocking NK3 receptors in the brain and gastrointestinal tract. (3-7)
Why Are These Drugs Dangerous?
Veozah was FDA approved in menopausal women with contra-indications to estrogen hormone replacement such as history of breast cancer, endometrial cancer, or venous thromboembolic disease. However, as Felice Gersh MD comments in the video below, the drug market segment for breast and uterine cancer patients is too small to generate enough profit to recoup drug development costs. However, there exists a much larger and more lucrative market. This larger market includes all the “hormone averse” women who fear hormones. A critical analysis of advertising for Veozah reveals targeting of hormone averse post menopausal women, meaning women who have been brainwashed by the drug industry to fear estrogen. This is a much larger market. Dr. Felice Gersh says in the below video, “this breaks my heart”. We will explain this below. (8 )
Drug Marketing to the Hormone Averse Woman
The Veozah drug marketed off-label to “hormone averse” women will create a windfall for the drug industry and a catastrophe for the patient. Menopause is an estrogen deficiency disease, and requires estrogen, not a NK3 receptor blocker that addresses only thermoregulation while ignoring the rest of the body. Night sweats and Hot Flashes are only one of the many symptoms of menopausal estrogen deficiency described in my previous newsletter: Health Benefits of Menopausal Hormone Replacement.
An Even Larger Secondary Drug Market
Post menopausal estrogen deficiency creates numerous degenerative diseases which then each require their own drug treatment. These estrogen deficiency diseases are: osteoarthritis, osteoporosis, depression, coronary artery disease, dementia, vaginal atrophy, genito-urinary symptoms to name a few, all treated with their own category of pharmaceutical drugs as seen with this list (below). Call me a conspiracy theorist, but this looks like a plan to create another drug windfall using pharmaceuticals to treat the estrogen deficiency diseases of menopause.
Disease Entity Drug
——————————————————–
Osteoporosis: Fosamax, Bisphosphonates
Osteoarthritis: Celebrex, NSAIDS
Depresssion: Prozac, Wellbutrin, SSRI antidepressants
Coronary Artery Disease: Statin Drugs
Dementia: Donepezil (Aricept)
Weight Gain : Phentermine, Ozempic
Cognitive Dysfunction: Ritalin and Adderal
Chronic Fatigue: Amphetamines
Vaginal Atrophy: Prasterone
Recurrent Urinary Tract Infections: Antibiotics
How to Make Your Patient Hormone Averse
Imagine if every primary care and OB/GYNE doctor started handing out this Veozah drug off-label to every”hormone averse” post menopausal patient. Maybe the patient didn’t start that way, but they sure became “hormone averse” after a short conversation with their primary care doctor explaining the “evils” of estrogen. All of these post-menopausal women should be taking estrogen. They have no history of breast or uterine cancer and therefore have no contraindications to estradiol, which is a far superior treatment compared to Veozah.
Everything Seems OK
Once starting Veozah drug, the night sweats and hot flashes resolve, and the patient is happy, thinking everything is going OK. However, after a few years, after it is too late, the patient will realize that their osteoarthritis, osteoporosis, cognitive dysfunction, genitourinary symptoms, vaginal atrophy, depression and chronic fatigue are due to estrogen deficiency. They will realize they have been misguided and lied to. They should have been taking estradiol all along. They may then seek out a different physician who is willing to give them real estrogen hormone replacement.
Withdrawal Effects of Blocking Neurotransmitter Receptors
What happens when women stop the Veozah drug? The night sweats and hot flashes return with a vengeance. This is a drug withdrawal effect commonly observed for all neurotransmitter receptor blocking drugs. The neurons compensate for the Veozah drug by making more receptors which are upregulated. This is the same mechanism for drug addiction with other neurotransmitter blocker drugs such as Amphetamines, Ritalin, Adderal, Methamphetamine etc. When the patient stops taking the drug, the withdrawal effects of debilitating night sweats and hot flashes force the patient to go back on the drug. This is the definition of an addictive drug. It is impossible to get off. The patient discovers she must be on Veozah for life or suffer the withdrawal effects of even worse debilitating night sweats and hot flashes.
No Long Term Studies – Drug Discontinuation Effects?
The Veozah hot flash study lasted 12 weeks, with another 40 weeks of blinded observation. Astella Pharmaceuticals, the drug manufacturer funding the studies, did not report on what happens when the drug is discontinued. The FDA approved the drug without considering long term effects of drug discontinuation, or any long term effects of blocking Neurokinin receptors of neurons of the hypothalamus of the brain. Neurokinin receptors are present throughout the body in various organ systems, mainly the gastrointestial tract. What happens when these are blocked? We do not know.
Felice Gersh MD Veozah: The new nonhormonal drug for hot flashes
In this 17 minute video by Dr. Felice Gersh, an integrative OB/Gyne doctor, Dr. Gersh expresses many of the same concerns mentioned above. The drug company advertising targets all “hormone averse” post menopausal women. potentially leading to a catastrophe for the menopausal patient not receiving estrogen, the correct treatment. The transcript can be found in the reference below. (8)
Veozah Advertisement – Notice no mention thisVeozah drug should be limited to women with active Breast Cancer and Uterine Cancer…
Articles with Related Interest
Health Benefits of Menopausal Hormone Replacement.
All Bioidentical Hormone Replacement Articles.
FDA Approval for Paxil for Hot Flashes A Cruel Joke ?
Jeffrey Dach MD
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Davie, Fl 33314
954-792-4663
Links and References
1) Lederman, Samuel, et al. “Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study.” The lancet 401.10382 (2023): 1091-1102.
The study was placebo-controlled for 12 weeks followed by a 40-week blinded extension to assess the maintenance of effect.Funded by Astellas Pharma.
2) Shaukat, Ayesha, et al. “Veozah (Fezolinetant): A Promising Non‐Hormonal Treatment for Vasomotor Symptoms in Menopause.” Health Science Reports 6.10 (2023): e1610.
The primary manifestation of the drug’s side effects consisted of various undesirable symptoms such as abdominal pain, diarrhea, insomnia, backache, hot flushes, and increased hepatic transaminases.
3) Blondeau, C., N. Clerc, and A. Baude. “Neurokinin-1 and neurokinin-3 receptors are expressed in vagal efferent neurons that innervate different parts of the gastro-intestinal tract.” Neuroscience 110.2 (2002): 339-349.
neurokinin-1 and neurokinin-3 receptors are involved in the parasympathetic control of digestive functions.
4) Sanger, Gareth J. “Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain.” British journal of pharmacology 141.8 (2004): 1303-1312.
5) Sanger, Gareth J., et al. “Defensive and pathological functions of the gastrointestinal NK3 receptor.” Vascular pharmacology 45.4 (2006): 215-220.
6) Poole, Daniel Philip, et al. “Stimulation of the neurokinin 3 receptor activates protein kinase Cε and protein kinase D in enteric neurons.” American Journal of Physiology-Gastrointestinal and Liver Physiology 294.5 (2008): G1245-G1256.
Tachykinins, acting through NK(3) receptors (NK(3)R), contribute to excitatory transmission to intrinsic primary afferent neurons (IPANs) of the small intestine. Although this transmission is dependent on protein kinase C (PKC),
7) Mishra, Amrita, and Girdhari Lal. “Neurokinin receptors and their implications in various autoimmune diseases.” Current Research in Immunology 2 (2021): 66-78.
Neurokinin receptors are ubiquitously expressed on the nervous and immune systems and control various physiological functions and are associated with multiple immunopathological conditions. Several immune cells including B cells, T cells, DCs, and macrophages express NK1Rs and modulate immune response (Mathers et al., 2007; Morelli et al., 2020).
Neurokinin receptors are widely expressed in the various systems including the nervous, cardiovascular, genitourinary, immune, digestive system. They are also expressed in different tissues and glands including the salivary gland, skin, and muscles (Costa et al., 2006; Eglezos et al., 1991; Evangelista, 2001; Green et al., 2006; Renzi et al., 2000; Satheeshkumar and Mohan, 2014). Distributions of neurokinin receptors are very uneven among the various organs. NK1R and NK3R receptors are present in the central nervous system and peripheral tissues.
8) Veozah: The new nonhormonal drug for hot flashes | Felice Gersh, MD 17 minute video
Transcript: Many women are living in fear of what should be a beloved hormone of the body, ovarian produced estradiol. At menopause, we lose our ovarian production of estradiol.
So, because there are so many women who are fearful of hormones like estrogen for no good reason other than as an offshoot of that unfortunate study (WHI 2002). The women’s health initiative from over 20 years ago, which just created an avalanche of negativity, which we are going to talk about that again much more so that you understand the DATA that all of this negativity was based on, which is bad data, but nevertheless the legacy has persisted. I am trying to get rid of it, change the whole paradigm of thinking about hormones from one of negativity to love and positivity. But because the negativity is so prevalent , drug manufacturers, and their researchers have been trying to find alternatives to estrogen to treat night sweats and hot flashes.
Estrogen is involved with regulating temperature. So when we go through menopause and have estrogen deficiency, Hot flashes and Nights sweats are triggered by this particular peptide neurokinin3 (NK3). This peptide is made in the hypothalamus of the brain where the thermoregulatory centers reside. So the drug industry created a drug to block the receptor for NK3. How brilliant is that ? This drug blocks the receptor and is pretty effective at blocking night sweats and hot flashes. And I am totally for it for women who cant take estradiol. It is a small segment of the female population, but it does exist. What kind of a patient would that be? A woman who has an ongoing estrogen positive cancer, like breast cancer and endometrial cancer. Estrogen can cause these cancer to proliferate and grow more. And that is the reality. As a general statement, women with estrogen positive cancers will not be prescribed estrogen. So, this new drug, Veozah, gives them a good option.
Hooray and applause for this new pharmaceutical.
That is not a large enough audience to target this drug to.
So Now they are talking about not just marketing it of course to women who really shouldn’t be on estrogen, but to women who should be, who are now, in their words, “hormone averse”. They are growing that market by making women think it is good to be “hormone averse”, and to think it is better to use something that is non-hormonal. So, that is how they are promoting this. Like it is a great thing. Wow! A non-hormonal treatment for night sweats and hot flashes that may be as effective for that one thing as estrogen ! They are not saying it is better. They can not say it is better. They maybe can say it is as good. That remains to be seen.
By the way, they haven’t tested Veozah against estrogen. They don’t want to , I am sure. What did they test it against.? Placebo!. Okay. So guess what? It (Veozah) is better than nothing. That is for sure. Well a lot of things are better than nothing. Deep breathing is better than nothing. A fan is better than nothing. etc.
Veozah may really be as effective as estrogen because it is working on the pathway t activated when you don’t have estrogen, which activates the neurokinin receptor pathway. Maybe it is. That remains to be seen. Remember, the study was for 12 weeks. OK so definitely over 12 weeks, the drug is very good for reducing and potentially eliminating night sweats and hot flashes, and definitely better than nothing.
But what they are doing in their advertising breaks my heart. And I want you to know, please don’t listen to them unless you have breast or uterine cancer. Because otherwise, you are a candidate, in almost every case, for going on real estrogen, estradiol. Why would you take a drug (Veozah) that is only, and by the way they do emphasize this, they are being honest about it, the drug only treats the hot flashes and night sweats. It is not treating every other organ system that is benefited by estrogen. Let us name a few:
The cardiovascular system
The musculoskeletal system.
The neurologial system.
The gastro intestinal system.
The skin system.
The genitourinary system
every system!!
It is not benefiting any of them except by facilitating better sleep. I am giving them a thumbs up for: You will have better sleep, which is good for everything.
Estradiol has a direct benefit on all those organ systems.
So if you have a choice and there is no contraindication to take real estradiol, that is what should take.
But like a said, they dont have a big enough market for Veozah drugs to just market with women who have breast or uterine cancer. So, they want to market to all women. What a market that is! So, they are talking about the best non-hormonal, with this real implication, whoah! How great is that, NO-Hormones. Like Hormones are evil.
It would be WOW! we can make you feel great and never give you any nutrition. Oh well, that is processed foods. That didn’t work out too well either.
So here is the thing. Please know there is a role for this new drug. Know that it does have a benefit for reducing night sweats and hot flashes. For women with absolute contraindications to estrogen this could be fantastic. But know that if you can take estradiol, that is the way you should go.
Don’t be listening to this, WOW, women who are averse to hormones, now you have some great tool.
What the real thing should be, why are you averse to hormones? Who brainwashed you into thinking something that is essential for health is bad for you?
Hormones are there because they do everything. Losing them is natural. That doesn’t mean its naturally good. Aging is natural. Let me emphasize that. Natural as can be. That doesn’t mean aging is good for you. Your body is not getting better and better as you go through each decade from 50-60, 60-70, 70-80 to 90. But I want it to stay really fabulously healthy.
To help every organ system in your body, you will not take this drug instead of real estrogen. The generic name is fezolinetant, and the brand name is Veozah.
Well, that is not all. What is the price of this amazing new drug? The retail price is about 660 dollars per month. That is a lot of money not covered by insurance yet, but you can be sure they are hard at work trying to get it covered for some other crazy high price that somebody is going to pay through their health insurance premium, or it could be you just paying for it outright.
I am not saying hormone replacement drugs are cheap, but generally, those prices are nowhere near this price.
It (Veozah) will not help your brain. It will not help your heart, your arteries, your bones, your muscles, your bladder, your vagina, your skin, your eyes, your hair, . Its not going to help any of them. Estradiol will help all of these things.
Yes, it is modern medicine at its best to give more options. that are need for certain small but critically important segments of the population. Women dealing with breast and uterine cancer. It is a good thing to have this drug. I am happy it is here. But what do we know about its long term effects? NOTHING !
Does a peptide only work in one place in the body for only one function? NO!
If you give high doses, usual dosage is 45 milligrams, If you gie 90 mg. the side effects on the gastrointestinl tract are huge. This peptide also acts on the gut. Nothing does one thing. When you block a receptor for a peptide, guaranteed there are going to be side effects, both short term and long term.
If you can take real estradiol, make that your first choice.
I welcome this new drug, but not for women who can take the real hormone they need to reverse the side effects of night sweats and hot flashes and all the other effects in the body of an estrogen deficient human female.
Brisdelle
9) Brisdelle (Paroxetine) for Hot Flashes? Not a Great Idea
Diana Zuckerman, PhD, National Center for Health Research
10) Menopausal Hormone Replacement Health Benefits
December 29 2023
11) Hassan, Fatima, et al. “Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy.” Medicine 102.23 (2023).
In our review, we find that without the disruption of the estrogen levels among menopausal and post-menopausal women, hot flush symptoms could be controlled. However, common modalities of treatment of symptomatology comprise hormone replacement therapy with either progestogen and estrogen together or estrogen alone. While hormone replacement is efficacious and considered generally safe for women in the short term, longer use for 5 years or more is associated with increased thromboembolic disorders and bone fractures.[68–71] Therefore, there has been a cautionary recommendation associated with the long-term use of hormone replacement; women at risk of cardiovascular disease or malignancies including endometrial or breast have limited therapy options.[68,72–74] This review attends to the increasing demand for efficacious and novel treatment that can function as an alternative to hormone replacement therapy.
Although these studies offer valuable insights into the potential benefits of NK3R antagonists for postmenopausal women experiencing vasomotor symptoms, the short-term nature and varying concerns about the risk of bias in some trials highlight the need for further research to establish long-term safety and efficacy profiles.
While a preliminary safety and efficacy profile has been generated; further studies are required to corroborate existing knowledge of the intervention to confirm long-term safety. NK1/3 receptor antagonists generate optimistic evidence for menopausal women, the results of this study must be used with caution until more safety and efficacy testing are conducted to elucidate the effectiveness. Current randomized controlled trials provide moderately strong evidence that NK3R antagonists are a promising target for further pharmacological and clinical studies to limit the frequency and severity of hot flushes. The implications of the non-hormonal therapy extend beyond the scope of menopausal women only and can be used among women for estrogen deprivation in breast cancer and prostate cancer for androgen deprivation. There is also potential for NKB/NK3R signaling pathways to manage sex-hormone-dependent diseases that ought to be explored.
12) Conklin, Melissa, and Nanette Santoro. “Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause.” Therapeutic Advances in Reproductive Health 17 (2023): 26334941231177611.
In summary, estrogen deficiency in menopause leads to the upregulation of NKB and its receptor (NK3R) via the median preoptic nucleus, which receives input and projects to the autonomic thermoregulatory pathway leading to the hallmark symptom of cutaneous vasodilatation, VMS.11
The current mainstay of treatment for VMSs [vasomotor symptoms] of menopause is hormone therapy and it remains the most effective treatment. Systemic hormone therapy with estrogen alone or in combination with progestin is the most effective treatment for VMS.1 In users of oral estrogen or oral estrogen plus progestin compared to placebo showed a 75% reduction
in weekly hot flush frequency.1 Estrogen can be administered orally or transdermally via
patches, gels or sprays.
However, in standardized clinical trials that conform to the FDA guidance for studies of VMS treatment (which includes criteria that participants should have a minimum average of 7 hot flashes a day or 49 per week and the test agent must be compared to a concurrent placebo group), the NK3R antagonist compounds compare favorably to estrogen. This is remarkable, given that none of the nonhormonal alternatives
currently available for treating VMS have such efficacy.
Taken together, the newer NK targeting compounds appear to have high efficacy against VMS and reduce both frequency and severity. When additional measures have been sought, there appears to be an improvement in sleep, particularly for the NK3R antagonists.
Despite decades of research, the anatomical source of VMS has only recently been localized to the KNDy neurons in the hypothalamus. Prior to this discovery, estrogen
was the mainstay for the treatment of VMS and, for many years, was the only FDA-approved treatment for VMS. Women in whom estrogen was contraindicated were, therefore, often without recourse.
Targeting the NK3R on the KNDy neuron has proven to be a successful strategy for reducing or eliminating the bothersome VMS associated with menopause.
Management of Menopause Life Extension
13) Menopause & Perimenopause 06/2023 Contributor(s): Maureen Williams, ND; Shayna Sandhaus, PhD; Stephen Tapanes, PhD; Scott Fogle, ND; Franco Melis; Shanti Albani, ND
Importantly, while menopause is not a disease, it is associated with long-term changes in health and chronic disease risk, including:
Increased risk of cardiovascular disease 6
Alterations in glucose and lipid metabolism, leading to increased risk of overweight, obesity, and type 2 diabetes7
Bone loss and increased risk of osteoporosis 7
Declining muscle mass and strength, and increased risk of sarcopenia8
Brain changes, cognitive impairment, and increased risk of dementia 7,9
14) Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T. Menopause: a cardiometabolic transition. Lancet Diabetes Endocrinol. Jun 2022;10(6):442-456.
15) Lobo RA, Gompel A. Management of menopause: a view towards prevention. Lancet Diabetes Endocrinol. Jun 2022;10(6):457-470.
16) Buckinx F, Aubertin-Leheudre M. Sarcopenia in Menopausal Women: Current Perspectives. International journal of women’s health. 2022;14:805-819. doi:10.2147/IJWH.S340537. https://www.ncbi.nlm.nih.gov/pubmed/3...
17) Jett S, Schelbaum E, Jang G, et al. Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease. Front Aging Neurosci. 2022;14:948219. doi:10.3389/fnagi.2022.948219. https://www.ncbi.nlm.nih.gov/pubmed/3...
Genito-Urinary Symptoms of Menopause
vaginal itching, burning, and irritation, pain with intercourse and sexual dysfunction,
urinary frequency, urgency, pain, and incontinence, recurring vaginal and urinary tract infections
18) Nappi RE, Martini E, Cucinella L, et al. Addressing Vulvovaginal Atrophy (VVA)/Genitourinary Syndrome of Menopause (GSM) for Healthy Aging in Women. Front Endocrinol (Lausanne). 2019;10:561. doi:10.3389/fendo.2019.00561. https://www.ncbi.nlm.nih.gov/pubmed/3...
19) Brady PH, Gin GT, Rosenblum E, Wilkinson LD. Female Pelvic Conditions: Genitourinary Syndrome of Menopause. FP essentials. Apr 2022;515:32-42. https://www.ncbi.nlm.nih.gov/pubmed/3...
20) Peters KJ. What Is Genitourinary Syndrome of Menopause and Why Should We Care? Perm J. May 2021;25doi:10.7812/TPP/20.248. https://www.ncbi.nlm.nih.gov/pubmed/3...
Weight Gain
Approximately 60–70% of women experience weight gain as a symptom of menopause. On average, women gain about 1.5 pounds per year between ages 50 and 60 years.
21) Kodoth V, Scaccia S, Aggarwal B. Adverse Changes in Body Composition During the Menopausal Transition and Relation to Cardiovascular Risk: A Contemporary Review. Womens Health Rep (New Rochelle). 2022;3(1):573-581. doi:10.1089/whr.2021.0119. https://www.ncbi.nlm.nih.gov/pubmed/3...
Sleep Problems
Anxiety and Depressed Mood
22) Bromberger JT, Kravitz HM, Chang Y, et al. Does risk for anxiety increase during the menopausal transition? Study of women’s health across the nation. Menopause. May 2013;20(5):488-95. doi:10.1097/GME.0b013e3182730599. https://www.ncbi.nlm.nih.gov/pubmed/2...
23) Bromberger JT, Schott LL, Kravitz HM, et al. Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition: results from the Study of Women’s Health Across the Nation (SWAN). Archives of general psychiatry. Jun 2010;67(6):598-607. doi:10.1001/archgenpsychiatry.2010.55. https://www.ncbi.nlm.nih.gov/pubmed/2...
Cognitive Dysfunction
24) Maki PM, Henderson VW. Cognition and the menopause transition. Menopause. Jul 2016;23(7):803-5. doi:10.1097/GME.0000000000000681. https://www.ncbi.nlm.nih.gov/pubmed/2...
25) Mosconi L, Berti V, Dyke J, et al. Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition. Sci Rep. Jun 9 2021;11(1):10867. doi:10.1038/s41598-021-90084-y. https://www.ncbi.nlm.nih.gov/pubmed/3...
Physical and Mental Exhaustion
More women report physical and mental exhaustion during perimenopause than in the premenopausal stage, and the percentage increases after menopause, even when stress levels are low.22
pdf
26) Giannini, Andrea, et al. “Neuroendocrine changes during menopausal transition.” Endocrines 2.4 (2021): 405-416.
However, early treatment initiators will probably gain more profit than harm by improving
bothersome symptoms, while obtaining offset benefits like cardiovascular risk reduction,
increase in bone mineral density and reduction in bone fracture risk, decrease in colorectal cancer risk and in overall mortality [62].
Conclusions
Menopause is the last phase in a long and complex cascade of events occurring both
in the CNS and in the ovaries. Several neuroendocrine changes and hypoestrogenism play a key role in these modifications and to cause vasomotor symptoms, migraine, depression or anxiety, cognitive disorders.
Hair Loss
27) Rinaldi, Fabio, et al. “The Menopausal Transition: Is the Hair Follicle “Going through Menopause”?.” Biomedicines 11.11 (2023): 3041.
28) Zouboulis, C. C., et al. “Skin, hair and beyond: the impact of menopause.” Climacteric 25.5 (2022): 434-442.
29) Bravo, Bruna, et al. “Dermatological Changes during Menopause and HRT: What to Expect?.” Cosmetics 11.1 (2024): 9.
Muscle Pain
30) Watt FE. Musculoskeletal pain and menopause. Post Reprod Health. Mar 2018;24(1):34-43. doi:10.1177/2053369118757537.
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VAsomotor Symptoms
31) Thurston RC. Vasomotor symptoms: natural history, physiology, and links with cardiovascular health. Climacteric : the journal of the International Menopause Society. Apr 2018;21(2):96-100. doi:10.1080/13697137.2018.1430131. https://www.ncbi.nlm.nih.gov/pubmed/2...
The average duration of frequent or moderate-to-severe menopausal hot flashes is 7–10 years! And many women have mild hot flashes even longer.15
Treatments
32) Mehta J, Kling JM, Manson JE. Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts. Front Endocrinol (Lausanne). 2021;12:564781. doi:10.3389/fendo.2021.564781. https://www.ncbi.nlm.nih.gov/pubmed/3...
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Enter Veozah, also known as fezolinetant, the pioneer non-hormonal drug sanctioned by the FDA to treat moderate to severe hot flashes in menopausal women. It works by latching onto these hyperactive NK3 receptors in the brain, pacifying the neurons that spark off hot flashes, and effectively stepping into estrogen’s shoes in temperature control. Clinical trials indicate that Veozah cuts down the frequency and intensity of hot flashes significantly more than a placebo. Moreover, its effectiveness was maintained over a year-long research period, suggesting it could offer lasting benefits.
Veozah provides an alternative solution for women who cannot or do not wish to take hormone therapy. However, it’s worth highlighting the potential advantages of estrogen. Hormone therapy has shown its effectiveness in easing hot flashes and providing lasting health benefits, including improved bone density, heart health, mood, and sexual health
Veozah’s approval is a glimmer of hope for women struggling with menopausal hot flashes. Yet, its price tag—$550 for a month’s supply as set by the maker, Astellas Pharma—is a serious consideration. To help with affordability, Astellas Pharma has introduced a support program.
34) Veozah Is A New Non-Hormonal Drug for Hot Flashes Peoples Pharmacy
Veozah (fezolinetant) is a new non-hormonal treatment for the hot flashes of menopause. How well does it work and what are the downsides? Joe Graedon
-May 30, 2023
On May 12, 2023 the FDA announced that it “approved Veozah (fezolinetant), an oral medication for the treatment of moderate to severe vasomotor symptoms, or hot flashes, caused by menopause…It works by binding to and blocking the activities of the NK3 [neurokinin 3] receptor, which plays a role in the brain’s regulation of body temperature.
Estrogen reduces hot flashes by 75 to 90 percent,
women in the Veozahtrials averaged about 10 to 11 hot flashes a day before starting the clinical trial. Taking the placebo resulted in 3 to 4 fewer hot flashes a day.
Before starting Veozah, make sure your doctor has ordered liver function tests. Only take this drug if your liver is functioning normally. Once you start taking Veozah make sure you follow up with blood tests at 3, 6, and 9 months to make sure your liver is still OK.
“projected” price will be around $550 a month
================
35) AJN, American Journal of Nursing November 2023, Volume :123 Number 11 , page 22 – 23 [Free] Second Nonhormonal Drug for Menopausal Hot Flashes
Fezolinetant is a neurokinin 3 (NK3) antagonist that binds to NK3 receptors, blocking the activity of the receptor. The NK3 pathway helps to regulate gonadotropin-releasing hormone secretion and has been implicated in the generation of hot flashes. Too much NK3 signaling in the preoptic area of the brain produces abnormal temperature regulation when estrogen levels are low, causing the body to try to dissipate heat quickly. This leads to the vasomotor symptoms experienced by menopausal women.2
While estrogen is very effective at treating vasomotor symptoms, its widespread use has fallen out of favor. The only other nonhormonal drug approved for treating hot flashes is the selective serotonin reuptake inhibitor paroxetine (Brisdelle).
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
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The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2023 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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Published on February 28th, 2024 by Jeffrey Dach MD
The post The Dangers of Non-Hormonal Menopause Drugs appeared first on Jeffrey Dach MD.
February 25, 2024
Paradoxical Pro-Metastatic Effects of Chemotherapy
Paradoxical Pro-Metastatic Effects of Chemotherapy by Jeffrey Dach MD
One of my patients underwent chemotherapy for lymphoma with a good result. The chemotherapy induced a complete remission. The para-aortic and mediastinal nodal masses melted away, and the follow up PET scan was completely clean, a complete remission. However only 3 months later, the lymphoma returned with a vengeance, even more aggressive than before. Over the next 3 years this was repeated three times. Each remission was followed by a relapse with more aggressive cancer behavior.
Above header image : Killer T cells Surround a Cancer Cell, Courtesy of University of Basel and National Institute of Health (NIH)
Pro-metastatic Effects of Chemotherapy
In 2020, Dr. Crescenzo D’Aletio reviewed the medical literature on this effect, writing chemotherapy has paradoxical pro-metastatic effects:
This review highlights the paradoxical pro-metastatic effects of chemotherapy linking reactive responses to treatment to tumor relapse and metastasis formation through primary tumor remodeling and generation of a favorable pro-metastatic niche.(1)
Dr. Crescenzo D’Aletio goes on to explain the mechanism of at play. The chemotherapy kills the “bulk” tumor cells, yet leaves behind chemo-resistant cancer stem cells, which repopulate with greater metastatic potential.The cancer stem cells repopulate under the intense stimulation of a massive systemic inflammatory response characterized by massive cytokine and chemokine release.
Breast Cancer Example
In the below quote, Dr. Crescenzo D’Aletio describes chemotherapy induced cytokine release which activates both the Wnt/β-catenin and NF-κB pathways creating an inflammatory feedback loop in breast cancer:
In breast cancer, cytokines released by tumor cells after chemotherapy can activate both Wnt/β-catenin and NF-κB pathways that amplify the secretion of further cytokines able to establish an autocrine inflammatory forward-feedback loop enriching for chemoresistant CSCs.(1)
Lung Cancer Example
A common chemotherapy drug for lung cancer is cisplatin, which kills bulk cancer cells, yet triggers massive IL-6 cytokine release which contributes to chemoresistance and prometastatic effects, resulting in increased distant metastatic disease formation. Dr. Crescenzo D’Aletio writes:
For instance, cisplatin treatment of lung cancer cell lines and xenografts triggers an increased release of the pro-inflammatory cytokine IL-6 [Interleukin-6] , that contributes to chemoresistance of cancer cells by activating EMT [epithelial to mesenchymal transition] and up-regulating anti-apoptotic proteins and DNA repair associated molecules []… Interestingly, despite primary tumor shrinkage, cisplatin-selection and priming of chemoresistant and metastatic CD133+CXCR4+ cells [Cancer Stem cells] results in increased distant metastasis formation.(1)
Above image : Fig. 2. Mechanisms mediating pro-metastatic effects of chemotherapy at different tumor districts. Courtesy of Dr. Crescenzo D’Aletio.(1)
Dr. Crescenzo D’Aletio concludes that chemotherapy is overall unsatisfactory for control of metastatic cancer spread throughout the body, and actually induces this effect:
In several tumor types, chemotherapy has so far demonstrated an overall unsatisfactory potential to counteract and control metastatic dissemination even when a partial or complete response has been achieved at the primary tumor site []. This clinical issue could be in part related to host responses to chemotherapy activating reactive and reparatory mechanisms able to foster generation of CSCs [Cancer Stem Cells], primary tumor cells escape and distant site colonization [] (). (1)
Cracking Cancer Toolkit by Jeffrey Dach MD
Did you like this article? You may wish to read my book: Cracking Cancer Toolkit available on Amazon.
Articles With Related Interest:
Ivermectin, Antiparasitic, Anticancer Wonder Drug
Artemisinin Our Best Cancer Weapon
All Cancer Articles on This Blog
Jeffrey Dach MD
7450 Griffin Road Suite 180/190
Davie, Fl 33314
954-792-4663
References
D’Alterio, Crescenzo, et al. “Paradoxical effects of chemotherapy on tumor relapse and metastasis promotion.” Seminars in cancer biology. Vol. 60. Academic Press, 2020. At the primary tumor site, chemotherapy has been reported to promote selection of chemoresistant and disseminating tumor cells endowed with properties of cancer stem cells (CSCs) through activation of autocrine and paracrine self-renewing/survival pathways promoted jointly by therapy-selected tumor and stromal cells. Resistant CSCs represent seeds for tumor relapse and increased infiltration by immune cells, together with enhanced vascular permeability induced by chemotherapy, facilitates tumor cells intravasation, the first step of the metastatic cascade. As a consequence of primary tumor/metastasis re-shaping induced by chemotherapy, circulating tumor cells (CTCs) detected during therapy can display a shift towards a more mesenchymal and stem-like phenotype, conductive to increased ability to survive in the circulation and seed distant organs. At the metastatic site, host responses to therapy activate inflammatory pathways that ultimately facilitate tumor cells extravasation and metastatic colonization. Finally, cooperation of immune cells and endothelial cells at perivascular niches favors the extravasation of tumor cells endowed with high potential for metastasis initiation and protects them from chemotherapy.This review highlights the paradoxical pro-metastatic effects of chemotherapy linking reactive responses to treatment to tumor relapse and metastasis formation through primary tumor remodeling and generation of a favorable pro-metastatic niche.Jeffrey Dach MD
7450 Griffin Road Suite 190
Davie, Fl 33314
954-792-4663
www.jeffreydachmd.com
http://www.drdach.com
http://www.naturalmedicine101.com
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Disclaimer click here: http://www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2024 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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Published on February 25th, 2024 by Jeffrey Dach MD
The post Paradoxical Pro-Metastatic Effects of Chemotherapy appeared first on Jeffrey Dach MD.
February 2, 2024
Lies My Government Told Me about the C0\/lD \/axxine
Lies My Government Told Me about the C0\/lD \/a<
by Jeffrey Dach MD
Basically, everything the federal government told you about the C0\/lD \/a< was a LIE. One person in government who is not lying to you is Dr. Joseph Ladapo, Surgeon General for the State of Florida who announced a halt to the use of C0\/lD \/@< may result in genome integration. This is an adulterated product which should be pulled from the marketplace. Above header Image courtesy of Dr. Joseph Ladapo Surgeon General State of Florida.
Covid-19 Vaccine Expert Panel Briefing to the Massachusetts Legislature and Public Health Officials.
Watch and listen to Dr. Janci Chunn Lindsay’s Feb 1, 2024 Testimony for the Massachusetts Legislature regarding the COVID-19 Vaccine and it’s dangers. Dr. Lindsay is a Molecular Biologist and Toxicologist who holds a Ph.D. in Biochemistry and Molecular Biology. It’s time for Massachusetts to become the 30th state to pass laws to protect it’s citizens from the not “safe” not “effective” covid shot.
"Coronavirus genetic vaccines are dangerous gene therapies sold with lies. Almost everything that they told us about these gene therapies is a lie."
Listen to Dr. Janci Chunn Lindsay's Testimony for the Massachusetts Legislature regarding the COVID-19 Vaccine and it's dangers.… pic.twitter.com/2fARdyJecg
— HealthRightsMA (@HealthRightsMA) February 2, 2024
Conclusion: The C0\/lD “sh0t” is neither safe nor effective and should have been pulled from the market two years ago when safety signals were first observed. The latest studies are even more alarming. This product is a modern day Frankenstein. Stay away.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
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www.drdach.com
Click Here for: Dr Dach’s Online Store for Pure Encapsulations Supplements
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The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Link to this Article
Copyright (c) 2024 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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Published on February 2nd, 2024 by Jeffrey Dach MD
The post Lies My Government Told Me about the C0\/lD \/axxine appeared first on Jeffrey Dach MD.
January 11, 2024
Taxicab Medicine and Diagnostic Errors
Taxicab Medicine and Diagnostic Errors by Jeffrey Dach MD
Last week JAMA published a study by Dr. Auerbach entitled “Diagnostic Errors in Hospitalized Adults Who Died or Were Transferred to Intensive Care”, finding diagnostic errors were common in patients who had bad outcomes, who died in the hospital or required transfer to the ICU. Dr. Auerbach writes:
Among hospitalized adults transferred to the ICU or who died in the hospital, diagnostic errors were common, harmful, and had underlying causes, which can be used to design future interventions. (1)
I look upon this report as merely one small indicator of a larger problem, the multi decade “race to the bottom”. Institutional medicine has been transformed into “Taxi-Cab Medicine” .
What is Taxicab Medicine ?
Let us say you owned a taxi cab company and you needed drivers. Let’s not be too picky. Anyone with a driver’s license will do. Is there a problem with a driver? Just get rid of them, and any other driver will do as a replacement. This is what has happened to the practice of medicine in our major institutions. Skilled doctors have been transformed into automatons forced to mindlessly follow hospital guidelines. If the doctor has a problem with the hospital guidelines and insists on a different treatment, the doctor is fired and replaced, just like the taxi cab company. This is called “Taxicab Medicine”.
Drs. Paul Marik and Pierre Kory
An excellent example of this is the case of Drs. Paul Marik and Pierre Kory, both highly skilled and published ICU critical care doctors working within institutional medicine. These prestigious doctors refused to follow hospital guidelines which called for use of ineffective toxic drugs such as remdesivir. Instead, the two doctors treated their covid patients with Ivermectin, a highly effective and safe drug. Because of their refusal to follow the absurd hospital guidelines, based on optimizing hospital profit, both doctors Drs. Paul Marik and Pierre Kory were promptly fired and replaced by more obedient doctors. This is called “Taxicab Medicine”. How many doctors met a similar fate? Probably thousands. (10-11)
Skilled Doctors Are a Rare Breed
The net result of decades of Taxicab Medicine is this: all the older gifted and skilled doctors, who are a rare breed, have disappeared, and have been replaced by new inexperienced doctors who lack the skills needed to take care of sick hospitalized patients. They are not required to have any skills. Instead, the only requirement is to obediently follow hospital guidelines. Deviation with creative thinking is not allowed. (13-16)
Diagnosis Requires Deliberate Reflection and Clinical Reasoning
In 2023, Dr. Sílvia Mamede reviewed the thinking process required to make a correct medical diagnosis, ie: the use of deliberate reflection and clinical reasoning to reduce errors, writing:
Several approaches based on reflection have been proposed to reduce clinicians’ errors during diagnostic reasoning…
(1) Deliberate induction, that is: returning to the problem to gather more information in search of alternative explanations besides the initial one considered;
(2) Deliberate deduction, exploring the consequences of these new explanations through predictions of signs and symptoms that should be present if the diagnostic hypothesis generated for the patient problem were correct;
(3) Testing these predictions extensively against the data present on the problem at hand, which would lead to either hypothesis confirmation or falsification;
(4) Openness towards reflection, an attitude that makes a physician tolerate uncertainty and engage in thoughtful reasoning when confronted with a challenging problem; and
(5) Meta‐reasoning, the willingness to reflect upon one’s own thinking processes and critically review assumptions and conclusions. (16)
How to Master the Art of Diagnosis
In 2023, Dr. Taro Shimizu provided twelve tips for doctors to master the art of medical diagnosis, writing:
Tip 1: Apply basic medicine knowledge to diagnosis.
Tip 2: Learn cognitive psychology.
Tip 3: Learn the various phenotypes of each disease.
Tip 4: Practice, practice, practice.
Tip 5: Maximise analytical thinking.
Tip 6: Develop and utilise diagnostic thinking strategies.
Tip 7: Integrate new technologies in relation to diagnostic decision making.
Tip 8: “Visualise” patients’ history and physical findings.
Tip 9: Nurture the ability to extract information appropriately.
Tip 10: Apply three reflections for calibration.
Tip 11: Consider both Safety 1 and 2.
Tip 12: Apply adaptive expertise training. (13)
Conclusion: Medical Diagnosis involves a complex cognitive process applying medical knowledge to the patient, the patient history, examination, laboratory and imaging studies etc. Making the correct diagnosis is difficult and errors can be made. For the new inexperienced doctor in training, the practice of medicine is a highly complex undertaking requiring many years of mentorship under older, and more experienced physicians. This is a long and arduous process giving rise to a generation of gifted and skilled physicians. This has been squandered, and Institutional Medicine has been transformed into Taxicab Medicine. Do you want to take a taxi ?
Jeffrey Dach MD
7450 Griffin Road Suite 180/190
Davie, Fl 33314
954 792 4663
Articles with Related Interest:
Is This the End of Medicine in America?
Medical Conspiracies that Came True
Why Are One in Six on Psych Meds ?
Header Image Taxi Cab Courtesy of Wikimedia Commons
References
1) Auerbach, Andrew D., et al. “Diagnostic Errors in Hospitalized Adults Who Died or Were Transferred to Intensive Care.” JAMA Internal Medicine (2024).
Among hospitalized adults transferred to the ICU or who died in the hospital, diagnostic errors were common, harmful, and had underlying causes, which can be used to design future interventions.
2) Carver, Niki, Vikas Gupta, and John E. Hipskind. “Medical errors.” StatPearls [Internet]. StatPearls Publishing, 2023.
3) Kohn, Linda T., Janet M. Corrigan, and Molla S. Donaldson. “Errors in health care: a leading cause of death and injury.” To err is human: Building a safer health system. National Academies Press (US), 2000.
4) Donaldson, Molla S., Janet M. Corrigan, and Linda T. Kohn, eds. “To err is human: building a safer health system.” (2000).
5) Neelamma, P., et al. “An evaluation of medication errors among staff nurses working in medicine intensive care unit of tertiary care hospital.” National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022): 2061-2065.
6) Singh, V. P., and Gautam Biswas. “Disclosing Medical Errors: Why, When and How?.” Legal Issues in Medical Practice (2020): 31.
7) Costa, Claudia Regina de Barros, et al. “Strategies for reducing medication errors during hospitalization: integrative review.” Cogitare Enfermagem 26 (2021).
8) Gray, Serajaddin, et al. “Medication Errors and Reducing Interventions: A Mixed Study in a Teaching Hospital.” Journal of Pharmaceutical Care (2021): 3-12.
9) Graber, Mark. “Diagnostic errors in medicine: a case of neglect.” The joint commission journal on quality and patient safety 31.2 (2005): 106-113.
10) ACADEMIA’S WAR ON DR. PAUL MARIK
World-renowned Critical Care Specialist, Dr. Paul Marik, joins Del to talk about the harrowing fight to keep his medical license, after treating critically-ill Covid-19 patients with lifesaving early treatments that were against hospital policy. Fellow FLCCC co-founder, Dr. Pierre Kory, joins the conversation to reflect on their first battle against Academia; the shocking struggle with a corrupt medical system to utilize a life-saving, cheap, and safe protocol for sepsis, the leading cause of death in the world.
11) How I Lost Three ICU Jobs During the COVID-19 Pandemic – Job 1
Prior to COVID, I was a nationally known expert in Pulmonary & Critical Care Medicine. Despite the massive need for specialists like me across the US, I had to leave 3 different US medical centers. Pierre Kory, MD, MPA Jan 18, 2022
12) Mamede, Sílvia, and Henk G. Schmidt. “Deliberate reflection and clinical reasoning: founding ideas and empirical findings.” Medical Education 57.1 (2023): 76-85.
13) Shimizu, Taro. “Twelve tips for physicians’ mastering expertise in diagnostic excellence.” MedEdPublish 13.21 (2023): 21.
14) Mamede, Sílvia, et al. “Think twice: effects on diagnostic accuracy of returning to the case to reflect upon the initial diagnosis.” Academic medicine 95.8 (2020): 1223-1229.
15) Brush, John E., Jonathan Sherbino, and Geoffrey R. Norman. “Diagnostic reasoning in cardiovascular medicine.” bmj 376 (2022).
16) Mamede, Sílvia, and Henk G. Schmidt. “Deliberate reflection and clinical reasoning: founding ideas and empirical findings.” Medical Education 57.1 (2023): 76-85.
According to the findings, a reflective physician would tend to show:
(1) Deliberate induction, that is: returning to the problem to gather more information in search of alternative explanations besides the initial one considered;
(2) Deliberate deduction, exploring the consequences of these new explanations through predictions of signs and symptoms that should be present if the diagnostic hypothesis generated for the patient problem were correct;
(3) Testing these predictions extensively against the data present on the problem at hand, which would lead to either hypothesis confirmation or falsification;
(4) Openness towards reflection, an attitude that makes a physician tolerate uncertainty and engage in thoughtful reasoning when confronted with a challenging problem; and
(5) Meta‐reasoning, the willingness to reflect upon one’s own thinking processes and critically review assumptions and conclusions.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
www.drdach.com
Click Here for: Dr Dach’s Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dach’s Online Store for Nature’s Sunshine Supplements
Web Site and Discussion Board Links:
jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2024 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation
Published on January 11th, 2024 by Jeffrey Dach MD
The post Taxicab Medicine and Diagnostic Errors appeared first on Jeffrey Dach MD.
December 14, 2023
UK Parliament, Martin, Malone, Cory Dec 4, 2023
UK Parliament Testimony Andrew Bridgen’s Meeting Dec 4, 2023
David Martin UK Parliament Dec 4, 2023
Dr. Robert Malone UK Parliament Meeting December 4, 2023
Pierre Kory, UK Parliament Meeting December 4, 2023
https://www.ucsusa.org/resources/disi...
The Disinformation Playbook
How Business Interests Deceive, Misinform, and Buy Influence at the Expense of Public Health and Safety Published Oct 10, 2017 Updated May 18, 2018
The disinformation Playbook Union of concerned scientists The Fake, The Blitz, The Diversion, The Screen, The Fix
Header image courtesy of wikimedia commons.
……….
Jeffrey Dach MD
References:
1)Â Â Â Â UK Parliament Testimony Videos From MP Andrew Bridgen’s Historic Meeting Dec 4, 2023- Martin, Kory, Malone, by Dr Pierre Cory Substack
His talk showed with such easily comprehensible clarity that the concept of a mass coronavirus vaccination strategy was divorced from basic immunological principles â something many of us had been saying from the outset (plus knowing that no vaccine for corona had ever been shown to be safe – the previous ones all led to worse outcomes via antibody dependent enhancement).
===============================================
David Martin UK Parliament Dec 4, 2023
The last four years has merely been an orchestration to assault the liberties in theis country and around the world, pretending that this is some kind of public health emergency,pretending this is a justification for the inconceivable threat to liberties, and the violation of human rights, is actually nothing more than lip service to science.
The evidence starts in the UK in 1966 by the Wellcome fund as the preferred form of human manipulation in 1966. One year later the US and UK made an agreement that said we were going to modify and manipulate corona virus to see what can be done to infect, “the healthy population”. That was 1967, the year I was born.
This slow moving train wreck that we call operation warp speed only took 56 short years .
In 2011, an anti-trust collusion between the Welcome trust and the Rockefeller Foundation, Gates Foundation, NIAID, and the Chinese Center for Disease Control annd Prevention got together and established a mandate that said that by 2020 the world would accept “a universal vaccine”
Look at this statement by Peter Daszak National Academy of Sciences March 2015: “A key driver is the media, and the economics follow the hype. We need to use that hype to oour advantage to get to real issues. Investors will respond if they see profit at the end of the process.” Does that sound like a public health emergency to you? Or does that sound like a statement of treason? That is an act of international and domestic terorism, and that is the admission of that act.
In a few short days we will have Dr Peter Daszak testify in Congress that this thing was a random wvent that came out of Wuhan China, were a bat and a pangolin got together, and voila, we were there.
TRhat quote by Peter Daszak National Academy of Sciences March 2015 is conspiracy level language. I am using the legal definition of the term. This is the admission of conspiracy to committ act of terror.
One year later, 2016, it was announced the Human Wuhan-1 virus was “poised for human emergence.”
In 2002, the first patent was filed on the chimeric corona virus, patented to be infectious and replication defective, in other words it was actually weaponized. That is not an allegation.
That is a statement of fact, because in 2005, on the CV of Ralph Baric, it says “Synthetic Corona Viruses.Bio-hacking: Biological Warfare Enabling Technologies” . Does that sound like a public health response? Or is there an outside chance the reason why he unleashed 10 million dollars that year, and every other year, in non-competitive grants, from all the above referenced agencies. Is there any chance, they were actually building biological weapons?
I happen to have the credentials in the US since 2002, of being a biological weapons inspector. I know of what I speak. I briefed this matter first in 2002, and consistently ever since.
In September 18, 2019, we actually had the WHO, Global Preparedness Monitoring Board announced that there was going to be, in the time between sept 2019 and sept 2020, an accidental or intentional release of a respiratory pathogen. There is an operative word in there tht is quite alarming, the wrod “release”. That is not a leak. That is not an accidental escape.
This criminal conspiracy must be criminally prosecuted in this country is the racketeering, the WHO collusion with Wellcome Trust since the MRC in this country was founded. ANd in the US the Rockefeller foundation which funded the CDC, the malaria prevention program.
We must deal with the fact that this anti-trust collusion started in 1955. There is statute of limitations on these crimes. Criminal Collusion of the Gates Foundation, Wellcome Trust and Rockefeller Foundation can be prosrcuted for these crimes at the time they were committed. It was fraud then, it is fraud now resulting in the murder of civilisation around the world.
Eliza Manningham was head of the board of Trustees of Wellcome trust was also the head of MI-5, was th eone who sat at the helm of COVID when the September 19th launch of this campaign began.
You cannot escape the fact that MI-5 was directly involved in teh premeditation, and distribution of this particular campaign of terror.
I know that as an American, it is probably a bad idea for me to say that to this audience, and I could care less. The fact of tha matter is criminals exist in every strata of this government, and we need to be able to point that out.
Lets stop pretending that we have to ask the question: WHY? That is a nonsense question. In the 1980’s we conveniently had the HIV pandemic so we could justify the national vaccine immunity shield that was granted to the injection manufacturers at the time . Becasue the fact of the matter was the public was willing to go along with it Because they all knew AIDS was coming for them. We tried to get that immunity long before. But once we had the HIV scare, we could get the public to go along with immunity for vaccine manufacturerer, we know we are going to need it.
September of 2001, we all pretend to know what happened with the towers on the 11th, but we all forget what happened on the 28Th , which is when the defense department from their bio-weapons program released anthrax, and 4 short years later we had the PREP act. WHY? Because on 1991 we were killing people with anthrax vaccines in the GULF, and we needed to come up with a way to get the Adult Provisions for protection into the adult injections, because the childhood act didnt give them the cover that they needed. The PREP act gives us corporatae immunity.
So guess what SARS is? Nothing more than the 4 year later, see a pattern? ,preamble to the WHO IHR (International Health Regulations).
Dont pretend that you dont know. This was a set-up from the beginning to the end, and ladies and gentlement. This is all a marketing cover story to deprive me of liberty, and I am here to make sure that as long as I draw breath, I am fighting the impact.
====================================
Dr. Robert Malone UK Parliament Meeting December 4, 2023
Let us all disclose the data !!!
700 to 1,000 peer reviewed studies show a series of adverse effects , myocarditis, reproductive health damage in women, mentriual cycle damage, coagulopathy including stroike and blood clotting, damage to peripheral , ocular and centril nervous system, immunologic harms, and death.
What we have here is a rushed product, a rushed technology, a failure to provide respect for humans, in not allowing them to have informed consent, and furthermore, actively deploying, the most massive proaganda campaign in the history of the medern world to suppress the ability of the public to gain access, merely to have the knowledge
of what the adverse event risks are. I come to you with one request: Let us see the data.
===================================================
Pierre Kory, UK Parliament Meeting December 4, 2023
https://www.ucsusa.org/resources/disi...
The Disinformation Playbook
How Business Interests Deceive, Misinform, and Buy Influence at the Expense of Public Health and Safety Published Oct 10, 2017 Updated May 18, 2018
The disinformation Playbook Union of concerned scientists The Fake, The Blitz, The Diversion, The Screen, The Fix
……….
Published on December 14th, 2023 by Jeffrey Dach MD
The post UK Parliament, Martin, Malone, Cory Dec 4, 2023 appeared first on Jeffrey Dach MD.
December 8, 2023
Cambridge Finds Major Flaw in mRNA Technology
Cambridge Finds Major Flaw in mRNA Technology
A new study (Dec 2023) by Tom Mulroney et al., at the University of Cambridge found that one third of 21 patients injected with mRNA vaccine had off-target immune responses. The cause of this was identified as the synthetic RNA, pseudo-uridine in the mRNA sequence. This synthetic RNA causes a ribosomal “slippage” and misreading of the mRNA code 10% of the time, producing proteins contains nonsense sequences of amino acids. These “nonsense sequences” are then recognized by the immune system which mounts an immune reaction, the “off-target” immune response.
The “ribosomal slippage” can be fixed by removing the pseudo-uridine, and replacing it with plain old uridine, the natural version.
Conclusion: Off-target immune response is a severe flaw in the mRNA vaccine platform which is extremely dangerous and should prompt the withdrawal of the entire product line. Government and media have been blatantly lying to the public for three years now. The mRNA platform is neither safe nor effective as demonstrated in this Cambridge study.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
Links and References:
Researchers have discovered that misreading of therapeutic mRNAs by the cellâs decoding machinery can cause an unintended immune response in the body.
mRNA – or âmessenger ribonucleic acidâ – is the genetic material that tells cells in the body how to make a specific protein. Researchers from the Medical Research Council (MRC) Toxicology Unit have discovered that the cellular machinery that âreadsâ mRNAs âslipsâ when confronted with repeats of a chemical modification commonly found in mRNA therapeutics. In addition to the target protein, these slips lead to the production of âoff-targetâ proteins triggering an unintended immune response.
N1-methylpseudouridine â which are currently contained in mRNA therapies â are responsible for the âslipsâ along the mRNA sequence.
When the ribosome is confronted with a string of these modified bases called N1-methylpseudouridine in the mRNA, it slips around 10% of the time causing the mRNA to be misread and unintended proteins to be produced â enough to trigger an immune response. Removing these runs of N1-methylpseudouridine from the mRNAs prevents âoff-targetâ protein production.
unintended immune response occurred in one third of the 21 patients in the study who were vaccinated
The safety concern for future mRNA medicines is that mis-directed immunity has huge potential to be harmful, so off-target immune responses should always be avoided.â
2) Mulroney, T E et al: â(N)1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.â Nature, Dec 23.
3) Tom Mulroney Research Associate with the Willis Group (Unit Director, Professor Anne Willis) MRC Toxicology Unit
Gleeson Building Tennis Court Road University of Cambridge, CB2 1QR
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.comÂ
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
www.drdach.com
Click Here for: Dr Dachâs Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dachâs Online Store for Natureâs Sunshine Supplements
Web Site and Discussion Board Links:
jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician â patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2023 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a âfair useâ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation
Published on December 8th, 2023 by Jeffrey Dach MD
The post Cambridge Finds Major Flaw in mRNA Technology appeared first on Jeffrey Dach MD.
November 24, 2023
ADHD Drugs in Children Cause Toxic Overdose
ADHD Drugs in Children Cause Toxic Overdose
by Jeffrey Dach MD
In adults, brain stimulant drugs such as amphetamines and methylphenidate have been used and abused for decades by adults to stimulate the brain to obtain greater wakefulness, more rapid thinking, and more fluent verbal ability, etc. Methylphenidate (MPH) and cocaine have similar mechanisms of action. Both block dopamine and norepinephrine transporters, thus preventing re-uptake into the pre-synaptic neuron. This leads to greater accumulation of both dopamine and norepinehrine within the synaptic space, amplifying the post-synaptic signal. (See Schematic Diagram Below)
Above Image Courtesy of Dr Sara Loureiro-Vieira, (2017) : Fig. 2. Methylphenidate (MPH) Mechanism of Action on Monoamine Neurotransmitters. MPH binds to and blocks the dopamine and norepinephrine transporters which inhibits the re-uptake of dopamine and norepinephrine neurotransmitters into the pre-synaptic nerve ending. The increase of Dopamine and Norepinephrine in the synaptic space leads to enhanced postsynaptic signalling. (3)
Header Image at top courtesy of Volkow, Nora D.,2012. PET scan using tracer agent which shows activity of Dopamine Transporters in Basal Ganglia. Note reduced activity in Basal Ganglia after IV methylphenidate infusion indicating the drug blocks dopamine transporters. PET scans before and after Intravenous MP shows reduced Dopamine receptor availability in striatum for both untreated (naive) and chronically treated patients, reflecting increased Dopamine availability at the synaptic spaces elicited by the drug. (2)
ADHD Drugs Therapeutic Efficacy in Children
As discussed in my previous newsletter, adults have been using brain stimulants such as amphetamines and cocaine since the 1940’s as performance enhancing drugs, either obtained over-the-counter, a doctor’s prescription or from the street. Methylphenidate can be considered similar to cocaine in mode of action on the brain.
A Triumph of Clever Advertising over Common Sense
Use in children for ADHD is a new twist which was made possible by massive drug company advertising which increased methylphenidate use in the U.S. by 800 per cent from 1994 and 1999. In 2014, Dr. Allen Frances, the psychiatrist who chaired the DSM–IV task force,(the manual for mental health disorders, and the “bible” for psychiatrists), wrote:
Drug companies were given the means, the motive,and the message to disease monger ADHD and blow it up out of all proportion.They succeeded beyond all expectations in achieving a triumph of clever advertising over common sense. (11-13)
Opposite Effect In Children
Brain stimulants have the desired effect in Adults. They stimulate the brain as expected. However, when stimulant drugs are used in children, they have quite the opposite effect, causing depression of brain activity, an obvious indicator of toxic overdose. According to Dr. Peter Breggin, a child psychiatrist with extensive experience treating ADHD kids, this drug toxicity is the “therapeutic effect” of ADHD drugs in children, and the explanation for “suppression of spontaneous and social behaviors”, depression and apathy. In 1999, Dr. Peter Breggin writes:
The âtherapeuticâ effects of stimulants are a direct expression of their toxicity. Animal and human research indicates that these drugs often suppress spontaneous and social behaviors while promoting obsessive/compulsive behaviors. These adverse drug effects make the psychostimulants seemingly useful for controlling the behavior of children, especially in highly structured environments that do not attend to their genuine needs.(4)
Drug of Choice for ADHD
In ADHD kids, amphetamines and methylphenidate (Ritalin) are considered the drug of choice, transforming a misbehaved child exhibiting inattention, hyperactivity and impulsivity into a docile “zombie-like” child, now considered well-behaved by the teachers in the classroom.This seemingly miraculous remission in the child’s ADHD symptoms of hyperactivity, inattentiveness and impulsivity is a direct result of suppression of prefrontal cortical activity. This “therapeutic effect” of the ADHD drugs in children is actually a result of toxic over-dose which suppresses activity in the prefrontal cortex.
Electrophysiology Studies in Mice of Pre-Frontal Cortex on Methylphenidate
In 2013, fourteen years after Dr. Peter Breggin’s observations about methylphenidate effects in ADHD kids, Dr. Kimberly Urban showed that Dr. Breggin was quite correct. Electrophysiology studies of prefontal cortex neurons before and after methylphenidate (Ritalin) in adult and juvenile mice found that while adult mice respond normally to brain stimulants at commonly used therapeutic doses, juvenile mice with developing brains are hypersensitive to this same dosage, resulting in toxic over-dose which suppresses rather than stimulates brain activity. (1)
Even Extremely Small Doses Are Toxic in Children
Dr. Kimberly Urban’s experiments even used extremely small doses of methylphenidate in juvenile mice finding this caused the same paradoxical effect. See Dr. Kimberly Urban’s chart below: (1)
Above image from Fig 1 (Urban, 2013): MPH=Methylphenidate (Ritalin).
A) Juvenile Mice: Upper Frame Left side, Blue Ellipse and Arrow: Comparison of action potentials in prefrontal cortex neurons in juvenile mice (upper frame) and adult mice (lower frame) injected with single dose saline upper graph, and single dose methylphenidate lower chart. Notice decreased frequency of action potential spikes after MPH in juvenile mice, indicating depression of brain activity in PFC (Pre Frontal Cortex) from single dose MPH.
A) Juvenile Mice: Upper Frame Right Side: Green Ellipse/Arrow shows action potential spikes after chronic saline (Green Ellipse and Arrow) or after chronic MPH (Red Ellipse and Arrow). Notice chronic MPH use decreases frequency of spikes, which then stops short, indicating severe depression of prefrontal cortex neurons in juvenile mice.
B) Adult Mice Lower Frame: Green Arrow and Ellipse shows chronic Saline given to Adult mice (serving as controls), while Red Arrow and Ellipse shows Chronic MPH administration to the adult mice. Notice chronic MPH dosage increases frequency of action potential spikes in adult mice compared to saline controls indicating increased stimulation of PFC neurons, the opposite of the depressive effect in juvenile mice.
Long Term Brain Alterations
In addition to confirming Dr. Breggin’s observations 14 years earlier, Dr. Urban found long term and possibly permanent alteration in brain chemistry, and function from chronic methylphenidate use in juvenile mice, raising the question of chronic brain alteration in children on ADHD drugs. This is also known as brain damage. Ample animal and human studies in the medical literature support this notion that long term use of ADHD drugs may cause alteration in brain chemistry, function, and behavior, some of which may remain permanent. (3-10)(14-19)
In 2017, Dr. Kimberly Urban writes:
Adolescent MPH [Methyphenidate] exposure was found to reduce social play, impair pattern learning and reversal learning, increase locomotor hyperactivity, and response to cocaine, sometimes lasting into adulthood. Early exposure to MPH has also been shown to result in increased anxiety lasting into adulthood and alter circadian rhythms. (18-19)
Conclusion:
In 1999, Dr Peter Breggin made observations about the effects of brain stimulants on ADHD children, namely the therapeutic effect is a direct result of drug toxicity. Later in 2013, Dr. Breggin was shown to be quite correct by Dr. Kimberly Urban’s painstaking electrophysiology studies in animals. These studies and others show that the juvenile brain is hypersensitive to the effect of brain stimulants, producing the paradoxical effect of brain suppression. When stimulant drugs are given to adults, they stimulate the brain and serve as performance enhancers. However, when given to children, these drugs have the opposite effect, suppressing and depressing brain function. Even small doses of ADHD brain stimulant drugs are toxic to children. This toxicity accounts for the “therapeutic effect” in ADHD children, and may result in long-term and even permanent alterations in brain chemistry and function. In my opinion, the medical use of brain stimulants in children is an iatrogenic catastrophe which should be halted immediately. (1-19)
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.comÂ
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
www.drdach.com
Articles with Related Interest:
The ADHD Drug Epidemic Amphetamines and Methylphenidate
Hypervaccination ADHD Autism and Neurodevelopmental Disorders
ADHD Attention Deficit Syndrome Part Two
Attention Deficit Disorder Exposed as Drug Marketing Ploy
Lithium Orotate the great Protector
More on Anti-Inflammatory Effects of Chinese Skullcap
References:
1) Urban, Kimberly R., and Wen-Jun Gao. âMethylphenidate and the juvenile brain: enhancement of attention at the expense of cortical plasticity?.â Medical hypotheses 81.6 (2013): 988-994.
2) Volkow, Nora D., et al. “Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder.” Journal of neuroscience 32.3 (2012): 841-849. Headre image is Fig1. Averaged DA D2/D3 receptor availability (BPND) images for the [11C]raclopride scans done after intravenous placebo and after intravenous MP (iv-MP) for the treatment-naive and long-term treatment conditions. Intravenous MP reduced DA D2/D3 receptor availability in striatum in both conditions, reflecting the DA increases elicited by the drug.
3) Loureiro-Vieira, Sara, et al. “Methylphenidate effects in the young brain: friend or foe?.” International Journal of Developmental Neuroscience 60 (2017): 34-47.
Dr. Peter Breggin on the Safety and Efficacy of ADHD Drugs
4) Breggin, Peter R. âPsychostimulants in the treatment of children diagnosed with ADHD: Risks and mechanism of action.â International Journal of Risk & Safety in Medicine 12.1 (1999): 3-35.
Millions of children in North America are diagnosed with attention deficit/hyperactivity disorder and treated with psychostimulants such as methylphenidate, dextroamphetamine, and methamphetamine. These drugs produce a continuum of central nervous system toxicity that begins with increased energy, hyperalertness, and overfocusing on rote activities. It progresses toward obsessive/compulsive or perseverative activities, insomnia, agitation, hypomania, mania, and sometimes seizures. They also commonly result in apathy, social withdrawal, emotional depression, and docility. Psychostimulants also cause physical withdrawal, including rebound and dependence. They inhibit growth, and produce various cerebral dysfunctions, some of which can become irreversible. The âtherapeuticâ effects of stimulants are a direct expression of their toxicity. Animal and human research indicates that these drugs often suppress spontaneous and social behaviors while promoting obsessive/compulsive behaviors. These adverse drug effects make the psychostimulants seemingly useful for controlling the behavior of children, especially in highly structured environments that do not attend to their genuine needs.
5) Sadasivan, Shankar, et al. âMethylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice.â PloS one 7.3 (2012): e33693.
6) Cavaliere, Carlo, et al. âMethylphenidate administration determines enduring changes in neuroglial network in rats.â European Neuropsychopharmacology 22.1 (2012): 53-63.
7) Lagace, Diane C., et al. âJuvenile administration of methylphenidate attenuates adult hippocampal neurogenesis.â Biological psychiatry 60.10 (2006): 1121-1130.
8) Fotopoulos, Nellie H., et al. âCumulative exposure to ADHD medication is inversely related to hippocampus subregional volume in children.â NeuroImage: Clinical 31 (2021).
9) Solleveld, Michelle M., et al. âAge-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients.â NeuroImage: Clinical 15 (2017): 812-818.
10) Carlezon Jr, William A., Stephen D. Mague, and Susan L. Andersen. âEnduring behavioral effects of early exposure to methylphenidate in rats.â Biological psychiatry 54.12 (2003): 1330-1337.
The Manipulation of Data and Attitudes about ADHD
11) Leo, Jonathan, and Jeffrey Lacasse. âThe Manipulation of Data and Attitudes about ADHD: A Study of Consumer Advertisments.â Rethinking ADHD: from brain to culture (2009): 287-312.
Between 1994 and 1999, the production of Ritalin increased eight hundred percent, with ninety percent of it being consumed in the United States
ADHD has been the subject of considerable controversy over the years. It has no biological diagnostic markers; it has been theorized to be over-diagnosed in Western countries; and it can be treated by both
psychosocial and pharmacological interventions. In addition, the most popular treatments for ADHD are Schedule II pharmaceuticals â psychostimulant drugs, such as methylphenidate or amphetamine, which carry both addictive properties and the risk of iatrogenic harm, and are largely prescribed to a vulnerable population
12) Leo, Jonathan, and Jeffrey R. Lacasse. âThe New York Times and the ADHD epidemic.â Society 52 (2015): 3-8.
Drug companies were given the means, the motive,and the message to
disease monger ADHD and blow it up out of all proportion.They succeeded beyond all expectations in achieving a triumph of clever advertising over common sense. Allen Frances, Chair, DSMIIV, February 12, 2014
13) These Are The Ridiculous Ads Big Pharma Used To Convince Everyone They Have ADHD Richard Feloni Dec 16, 2013, 3:29 PM EST
14) Bolaños, Carlos A., et al. “Antidepressant treatment can normalize adult behavioral deficits induced by early-life exposure to methylphenidate.” Biological psychiatry 63.3 (2008): 309-316.
15) Achat-Mendes, C., K. L. Anderson, and Y. Itzhak. “Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood.” Neuropharmacology 45.1 (2003): 106-115.
16) Carlezon Jr, William A., Stephen D. Mague, and Susan L. Andersen. “Enduring behavioral effects of early exposure to methylphenidate in rats.” Biological psychiatry 54.12 (2003): 1330-1337.
17) Bolanos, Carlos A., et al. “Methylphenidate treatment during pre-and periadolescence alters behavioral responses to emotional stimuli at adulthood.” Biological psychiatry 54.12 (2003): 1317-1329.
Results: The MPH-treated animals were significantly less responsive to natural rewards such as sucrose, novelty-induced activity, and sex compared with vehicle-treated control animals. In contrast, MPH-treated animals were significantly more sensitive to stressful situations, showed increased anxiety-like behaviors, and had enhanced plasma levels of corticosterone.
Conclusions: Chronic exposure to MPH during development leads to decreased sensitivity to rewarding stimuli and results in enhanced responsivity to aversive situations. These results highlight the need for further research to improve understanding of the effects of stimulants on the developing nervous system and the potential enduring effects resulting from early-life drug exposure.
18) Urban, Kimberly R., and Wen-Jun Gao. “Psychostimulants as cognitive enhancers in adolescents: more risk than reward?.” Frontiers in Public Health 5 (2017): 260.
The current dearth of knowledge on the doseâresponse curve, metabolism, and cognitive outcomes in adolescents following methylphenidate or other psychostimulant exposure may be perpetuating a perception of these drugs as âsafeâ when that might not be true for developing brains.
The first stimulant approved for ADHD treatment AMPH (Adderall©) blocks reuptake but also increases vesicular release of DA; the effect on DA release is the main action at low doses
stimulant medications seem to improve cognitive function in an inverted-U curve manner, with lower doses improving and higher doses impairing various aspects of cognition
adolescent MPH exposure was found to reduce social play, impair pattern learning and reversal learning, increase locomotor hyperactivity, and response to cocaine, sometimes lasting into adulthood (57â60). Early exposure to MPH has also been shown to result in increased anxiety lasting into adulthood and alter circadian rhythms (61â65).
The current dearth of knowledge on the doseâresponse curve, metabolism, and cognitive outcomes in juveniles and adolescents following MPH or other psychostimulant exposure may be perpetuating a perception of these drugs as âsafeâ for any age when that might not be true.
19) Urban, Kimberly R., et al. “A clinically-relevant dose of methylphenidate enhances synaptic inhibition in the juvenile rat prefrontal cortex.” Journal of reward deficiency syndrome and addiction science 2.3 (2017): 69.
Taken together, these results suggest that MPH administration to a healthy juvenile may enhance excitation of GABAergic interneurons; thus shifting the excitation-inhibition balance in the prefrontal cortex towards inhibition, and depressing overall prefrontal cortical activity. Our findings also indicate that the adolescent brain is more sensitive to MPH than previously thought, and dose ranges need to be reconsidered for age as well as size.
============================================
Click Here for: Dr Dachâs Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dachâs Online Store for Natureâs Sunshine Supplements
Web Site and Discussion Board Links:
jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician â patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2023 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a âfair useâ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation
Last updated on November 25th, 2023 by Jeffrey Dach MD
The post ADHD Drugs in Children Cause Toxic Overdose appeared first on Jeffrey Dach MD.
October 17, 2023
Iodine, Thyroid and Real Breast Cancer Awareness Podcast
Iodine, Thyroid and Real Breast Cancer Awareness with Dr. Jeffrey Dach on the “Back to Human Podcast” by James Andriella
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Click Below to watch Podcast:
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Oct 13, 2023, Episode Description:
Welcome to the 28th episode of the Back to Human Podcast. On today’s episode we talk about why iodine is an essential nutrient, why it is important for optimal thyroid health and can potentially be preventative and curative for fibrocystic breast disease and breast cancer. Joining me on this episode is Dr. Jeffrey Dach. Dr. Dach has been practicing medicine since 1976. After 25 years of working in the Memorial Hospital System in South Florida as a diagnostic and interventional radiologist, Dr. Dach retired as a radiologist and started up his own practice TrueMedMD where he specializes in bioidentical hormones, natural thyroid and natural medicine. Dr. Dach is the author of several books including Natural Thyroid Toolkit, Cracking Cancer Toolkit, Heart book, Bioidentical Hormones 101 and Stop the Thyroid Madness. We cover a lot in this discussion. Some of the topics include:
⢠What is iodine and why is it an essential nutrient?
⢠Myxedema.
⢠What causes iodine deficiency?
⢠Selenium for autoimmune thyroid disease.
⢠How iodine deficiency is a direct cause of autoimmune thyroid disease.
⢠How iodine deficiency is the leading cause of mental retardation in the developing fetus.
⢠The introduction of iodized salt.
⢠Iodine increasing IQ.
⢠Sources of iodine.
⢠How coronary artery disease is correlated to low thyroid and how thyroid hormone has cured heart disease.
⢠The difference between natural desiccated thyroid and synthetic thyroid hormone.
⢠What labs are used to diagnose thyroid health and why should be not rely solely on TSH.
⢠How and why iodine is useful as a treatment for fibrocystic breast disease and breast cancer.
⢠Dermobromism when starting high iodine supplementation and adverse effects.
⢠Does estrogen make breast cancer grow?
⢠Testosterone as a breast cancer treatment
⢠Estrogen as a breast cancer treatment in postmenopausal women.
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Natural Thyroid Toolkit
If you liked this discussion about iodine, thyroid and preventing breast cancer, then you might like my new book, Natural Thyroid Toolkit available on Amazon. See the book cover, left image.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
===============================================
my blog: www.jeffreydachmd.comÂ
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
www.drdach.com
Click Here for: Dr Dachâs Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dachâs Online Store for Natureâs Sunshine Supplements
Web Site and Discussion Board Links:
jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician â patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright (c) 2023 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a âfair useâ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation
Published on October 17th, 2023 by Jeffrey Dach MD
The post Iodine, Thyroid and Real Breast Cancer Awareness Podcast appeared first on Jeffrey Dach MD.
September 26, 2023
Rapid Progression of Lymphoma After Booster
Turbo Cancer: Rapid Progression of Lymphoma After Covid Booster
by Jeffrey Dach MD
A 31 year old male with a diagnosis of B-Cell lymphoma called my office to ask me for a second opinion. His oncologist scheduled a series of chemotherapy treatments to treat the lymphoma, however before starting the chemotherapy, the oncologist insisted the patient should receive two Pfizer Covid vaccine shots, explaining the Covid vaccine shots would “protect the patient during chemotherapy”.
A quick review of the medical literature turned up a number of troubling case reports of “turbo cancers” after Covid vaccination. These are rapidly progressing cancers in young people after receiving a booster shot. These turbo cancers were first reported as hematologic cancers such as lymphomas and leukemias arising shortly after covid vaccination. We now have case reports of virtually all other cancers arising shortly after Covid vaccination. The mechanism is disturbance of the cancer surveillance function of our immune system.
My advice to the young man with lymphoma was to respectfully decline the Covid shots. In my opinion, the risk of rapid progression, or turbo cancer, is too great. Above Header image: courtesy of Dr Serge Goldman and Frontiers in Medicine 8 (2021): 2409. (1)
A Case Report of Turbo Cancer: Lymphoma
The patient is a 66 year old man who presented with lymphoma 5 months after two Pfizer Covid vaccine shots. See Left Image: PET Scan, labeled September 8, shows extensive increased tracer uptake within malignant lymph nodes in cervical, axillary and peri-aortic lymph node chains.
At the time, the oncologist did not realize any connection between the two Pfizer shots and the patient’s lymphoma. The oncologists were planning to start chemotherapy, and in preparation decided to give the patient a Covid booster shot to protect him during chemotherapy. See vertical up arrow dated September 22. Within a few days after this shot, the patient felt his lymph nodes in the neck rapidly enlarging. The doctors ordered another PET scan, September 30, eight days after the Pfizer booster shot. To their horror, the final scan shows very rapid progression of lymphoma (ie “explosion”), with rapid growth as well as extensive spread of new lesions (See Right Image). This was the first example of a “Turbo Cancer” after Covid vaccination published in the medical literature by Dr. Serge Goldman in 2021. (1)
There have been many more since this first one. (2-7)
Dr. William Makis Discusses Turbo Cancer After Covid Vaccination: Interview on the Highwire with Del Bigtree, September 22, 2023.
Should Anyone Take the New Covid Booster (Monovalent XBB.1.5
BNT162b2) COVID-19 Vaccine?
September 7, 2023: Dr. Joseph Ladapo, the Surgeon General for the State of Florida issued guidance advising against taking the new Covid Booster, citing absence of clinical trials showing safety or efficacy. The only pre-market study for this new Pfizer vaccine was done in mice in groups of 10, i.e. Female Balb/c mice (10 per group). (26)
Dr. Ladapo also cites many studies around the globe showing negative efficacy. Negative efficacy means the vaccine increases ones risk for contracting Covid-19, not decreases it. The Covid vaccine also increases the risk of myocarditis associated with persistence of spike protein circulating in the blood stream and deposited in various organs of the body for up to six months after the shot. (10-25)
Florida's Surgeon General slams the new, untested mRNA vaccine:
“There’s essentially no evidence for it. There’s been no clinical trial done in human beings showing that it benefits people. There's been no clinical trial showing that it is a safe product for people…” pic.twitter.com/iefab6VPqZ
— Rebel News Canada (@RebelNews_CA) September 7, 2023
Just Another “Bad Vaccine”
Over the years, we have seen a number of “bad vaccines” introduced and then later pulled from the market. The Covid vaccine is another one of these “bad vaccines” which should have been pulled from the market a long time ago. They are not safe and they are not effective. Stay away.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
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my blog: www.jeffreydachmd.com
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
Articles with Related Interest:
Watch the entire 2 hour episode on the Highwire with Del Bigtree: Episode 338: TURBO TROUBLE
Dr. Peter McCullough on Ivermectin and Covid Vaccines
Explaining Damar Hamlin Cardiac Arrest on Field
Covid Vaccines, a time for Re-Assessment
Director of CDC, Rochelle Walensky Warns of ADE, Antibody Dependent Enhancement From Israel Data.
Israel Should Stop Ṗẝiẕḗr and Start l\/ḗrmḗctin Distribution
The Covid Vaccine is Safe and Effective ?
Could the Covid Vaccine be the Next Vioxx ?
Ivermectin for Covid, The Failure of American Medicine
Ivermectin Antiparasitic Anticancer Antiviral Wonder Drug
Links and references:
1) Goldman, Serge, et al. “Rapid progression of angioimmunoblastic T cell lymphoma following BNT162b2 mRNA vaccine booster shot: a case report.” Frontiers in Medicine 8 (2021): 2409.
2) Sekizawa, Akinori, et al. “Rapid progression of marginal zone B-cell lymphoma after COVID-19 vaccination (BNT162b2): A case report.” Frontiers in medicine 9 (2022): 963393.
3) https://www.frontiersin.org/articles/...
Sekizawa, Akinori, et al. “Rapid progression of marginal zone B-cell lymphoma after COVID-vaccination (BNTb): A case report.” The effect of COVID-19 on hematological disease diagnosis, management and outcomes (2023): 26.
4) Eens, Sander, et al. “B-cell lymphoblastic lymphoma following intravenous BNT162b2 mRNA booster in a BALB/c mouse: A case report.” Frontiers in Oncology 13 (2023).
5) Cavanna, Luigi, et al. “Non-Hodgkin lymphoma developed shortly after mRNA COVID-19 vaccination: report of a case and review of the literature.” Medicina 59.1 (2023): 157.
6) Zamfir, Maria-Alexandra, et al. “Hematologic malignancies diagnosed in the context of the mRNA COVID-19 vaccination campaign: a report of two cases.” Medicina 58.7 (2022): 874.
7) Ang, Shy-Yau, Yi-Fang Huang, and Chung-Ta Chang. “Ph-Positive B-Cell Acute Lymphoblastic Leukemia Occurring after Receipt of Bivalent SARS-CoV-2 mRNA Vaccine Booster: A Case Report.” Medicina 59.3 (2023): 627.
8) Jiang, Hui, and Ya-Fang Mei. “SARS–CoV–2 spike impairs DNA damage repair and inhibits V (D) J recombination in vitro.” Viruses 13.10 (2021): 2056.
9) Were Lab Animals Killed After mRNA Vaccination Trials to Hide Long-Term Adverse Consequences? Scientists could follow test animals for a while post-vaccination, to keep humans safe – but they chose not to Igor Chudov Jun 28, 2023
10) Yonker, Lael M., et al. “Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis.” Circulation 147.11 (2023): 867-876.
11) Forte, Elvira. “Circulating spike protein may contribute to myocarditis after COVID-19 vaccination.” Nature Cardiovascular Research 2.2 (2023): 100-100.
12) Aye, Yin Nwe, et al. “Acute myocardial infarction and myocarditis following COVID-19 vaccination.” QJM: An International Journal of Medicine 116.4 (2023): 279-283.
13) Amodio, Donato, et al. “Relapsing myocarditis following initial recovery of post COVID-19 vaccination in two adolescent males–Case reports.” Vaccine: X 14 (2023): 100318.
14) Fatima, Maurish, et al. “Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: a systematic review.” Clinical Cardiology 46.3 (2023): 243-259.
15) Knudsen, Benjamin, and Vinay Prasad. “COVID‐19 vaccine induced myocarditis in young males: A systematic review.” European Journal of Clinical Investigation 53.4 (2023): e13947.
16) Sim, Ju-Young, Seung-Yun Kim, and Eun-Kyoung Kim. “The incidence and clinical characteristics of myocarditis and pericarditis following mRNA-based COVID-19 vaccination in Republic of Korea adolescents from July 2021 to September 2022.” Osong Public Health and Research Perspectives 14.2 (2023): 76.
17) Mehta, Karina, et al. “COVID vaccine-associated myocarditis in an 8-year-old patient.” Cardiology in the Young 33.2 (2023): 334-335.
18) Witberg, Guy, et al. “Myocarditis after Covid-19 vaccination in a large health care organization.” New England Journal of Medicine 385.23 (2021): 2132-2139.
19) Mevorach, Dror, et al. “Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel.” New England Journal of Medicine 385.23 (2021): 2140-2149.
20) Truong, Dongngan T., et al. “Clinically suspected myocarditis temporally related to COVID-19 vaccination in adolescents and young adults: suspected myocarditis after COVID-19 vaccination.” Circulation 145.5 (2022): 345-356.
21) Rosner, Carolyn M., et al. “Myocarditis temporally associated with COVID-19 vaccination.” Circulation 144.6 (2021): 502-505.
22) Levin, Dan, et al. “Myocarditis following COVID-19 vaccination–a case series.” Vaccine 39.42 (2021): 6195-6200.
23) Craddock, Vaughn, et al. “Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19.” Journal of Medical Virology 95.2 (2023): e28568.
24) Craddock, Vaughn, et al. “Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19.” Journal of Medical Virology 95.2 (2023): e28568.
25) Craddock, Vaughn, et al. “Persistent presence of spike protein and viral RNA in the circulation of individuals with post-acute sequelae of COVID-19.” MedRxiv (2022): 2022-08.
26) Monovalent XBB.1.5, BNT162b2 COVID-19 Vaccine, ACIP Presentation September 12, 2023 by Dr. Modjarrad
Female Balb/c mice (10 per group) were experienced with a primary series of monovalent BNT162b2 Original vaccine and a 3rd booster dose of bivalent BNT162b2 (Original+BA.4/5) vaccine. Mice then received a 4th booster dose of either a bivalent BNT162b2 (Original+BA.4/5) or a monovalent BNT162b2 (XBB.1.5) vaccine. Data were generated by same pseudovirus neutralization assay and from sera of same mouse study presented at VRBPAC June 15, 2023 meeting (https://www.fda.gov/media/169541/down...).
Data on file: Pfizer-BioNTech. September 2023.
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Published on September 26th, 2023 by Jeffrey Dach MD
The post Rapid Progression of Lymphoma After Booster appeared first on Jeffrey Dach MD.
September 15, 2023
Making Coffee Out of This World by Jeffrey Dach MD
The very best coffee is made with fresh whole coffee beans, freshly ground and mixed with boiling water in a French Coffee Press. The most important component is the quality of the coffee beans. And among the very best beans are the Ethiopian Yirgacheffe beans (organic or fair trade). These are “out of this world”, and far better than Starbucks coffee. Also excellent is the Britt Costa Rica Organic Bajo Sombra (grown in the shade)..
Coffee Beans Should Look Like This:
First Step to Make Coffee:The first step is to boil water in the kettle. While waiting for the water to boil, get out your French coffee press, and remove the plunger. Also get out your electric coffee bean grinder. For my taste, the best coffee right now is the Ethiopian Yirgacheffe, Whole Bean.[image error]
The Coffee Bean Grinder: 
Fill the coffee grinder with whole beans, replace the lid, and turn on the grinder. After 30 seconds or so, the beans will be fully ground into small particles. Dump these small particles into the large glass beaker called a French Coffee Press. Above Left Image: Electric coffee grinder Courtesy Wikimedia Commons
A whistling kettle is recommended since it will alert you when the water comes to a full boil. Once boiling, the water is now ready to pour into the French coffee press. Be careful as you fill the glass beaker about ¾ full, because the water is scalding hot.
Left Image: French Coffee Press with plunger in center.Courtesy Wikimedia Commons
Stir once and let the coffee sit for a variable length of time depending on your taste and experience. I usually give it 30-60 seconds and then push down on the plunger which then pushes the coffee grounds down to the bottom of the glass beaker. Others suggest giving it 3-4 minutes before using the plunger.
This is how your coffee should look:
Now you can pour off the coffee into your coffee cup or mug. The surface should have a rich creamy bubbly look (see above image). I usually add a small amount of milk, and wait a few minutes to cool off, and then the coffee is ready to drink. This is the really good part. It’s heaven.
Left image is caffeine, and right image is adenosine. Note the red arrow points to a module in adenosine which is very similar to caffeine.
Caffeine is the Drug in Coffee
The active ingredient in coffee is a drug called caffeine, a stimulant of the central nervous system. This natural plant drug is the reason we all drink coffee. The chemical structure of caffeine (see above image) is similar to adenosine, which is an inhibitory neurotransmitter in the brain. Caffeine blocks the action of adenosine, and therefore acts as a brain stimulant. There are about 200,000 research articles on caffeine in the scientific and medical literature.(4) Because caffeine is a CNS stimulant, it can product dependence, tolerance, and withdrawal symptoms just like any other addictive drug.(3) 
Phospho Diesterase Inhibitor
Another mode of action of caffeine is blockage of an enzyme called Phosphodiesterase which normally degrades cyclic AMP. This allows the build-up of cyclic AMP which intensifies and prolongs epinephrine, a potent stimulant in the body. This also increases Cortisol.(5)
Left Image: Chemical Structure of Cyclic AMP, which has Adenosine with a phosphate group attached (Blue Ellipse =phosphate). Red Circle shows caffeine-like structure at the upper right.
As mentioned above, Caffeine is a Phosphodiesterase Inhibitor which increases epinephrine and cortisol.(5) Other PDI’s in medical use include Methylxanthines, aminophylline, theophylline and sildenafil.(6) According to Dr Anwar in a 2013 publication,
“Phospho-diesterase inhibitors (PDIs) have important vascular and myocardial protective effects and thus have shown therapeutic usefulness in the clinical settings for treatment of patients with heart failure, pulmonary hypertension, and coronary artery disease”.(6)
Long term health benefits of coffee consumption include reduction in all-cause mortality, reduction in neuro-degenerative diseases like Alzheimer’s and Parkinsons, reduction in various types of cancer.(7-11) Enjoy your cup of “Out of This World” Coffee, plant based Natural Medicine from your own kitchen.
Article with related Interest
Grocery Store as Minefield Aspartame
Adverse Health Effects of Diet Sodas
Jeffrey Dach MD
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References:
1) http://coffeescience.org/ www.coffeescience.org, a service of the National Coffee Association.
2) http://www.acnp.org/G4/GN401000165/CH161.html Caffeine : A Drug of Abuse? Roland R. Griffiths and Geoffrey K. Mumford
3) http://www.hopkinsmedicine.org/Press_releases/2004/09_29_04.html CAFFEINE WITHDRAWAL RECOGNIZED AS A DISORDER
4) http://scholar.google.com/scholar?q=caffeine&hl=en&lr= 191,000 research articles on Caffeine from Google Scholar
Cortisol Response
5) Lovallo, William R., et al. “Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels.” Psychosomatic medicine 67.5 (2005): 734.
After 5 days of caffeine abstinence, caffeine challenge doses caused a robust increase in cortisol across the test day (p < .0001). In contrast, 5 days of caffeine intake at 300 mg/day and 600 mg/day abolished the cortisol response to the initial 9:00 AM caffeine dose, although cortisol levels were again elevated between 1:00 PM and 7:00 PM (p = .02 to .002) after the second caffeine dose taken at 1:00 PM. Cortisol levels declined to control levels during the evening sampling period.
Conclusion Cortisol responses to caffeine are reduced, but not eliminated, in healthy young men and women who consume caffeine on a daily basis.
—————————-
caffeine PD inhibitor
6) Anwar, Siraj, and M. H. Alchter. “Cardiovascular and other pharmacological approaches of phosphodiesterase enzyme inhibitors.” Int. J. Adv. Pharm. Ned. Bioallied Sci 1 (2013): 35-39.
Phosphodiesterase inhibitors (PDIs) have important vascular and myocardial protective effects and thus have shown therapeutic usefulness in the clinical settings for treatment of patients with heart failure, pulmonary hypertension, and coronary artery disease (Boswell-Smith, 2006 Guazzi et al., 2007).
The therapeutic efficacy of PDE inhibitors in myocardial protection after ischemic preconditioning (IPC) is well documented
PDIs prevent the breakdown of nitric oxide (NO)-driven cGMP, primarily in vascular smooth muscle cells, and thus act as potent vasodilators.
Non-selective PDE inhibitors including theophylline and papaverine have been used as therapeutic agents for over 70 years for a range of diseases. However, it is only in the last 10 years, that potent PDE selective drugs have been proved as effective therapeutic agents in the treatment of disease, and the worldwide success of sildenafil in the treatment of erectile dysfunction is evidence of the effect of such drugs.
We all drink coffee for the caffeine, a CNS stimulant whose chemical structure is similar to adenosine, an inhibitory neurotransmitter in the brain. Caffeine blocks the action of adenosine, thus exerting CNS stimulant effects. Abrupt cessation may induce withdrawal symptoms like any other addictive drug. Caffeine is also a Phosphodiesterase Inhibitor which increases epinephrine and cortisol. Other PDI’s in medical use include Methylxanthines, aminophylline, theophylline and sildenafil, According to Dr Anwar in a 2013 publication, “Phospho-diesterase inhibitors (PDIs) have important vascular and myocardial protective effects and thus have shown therapeutic usefulness in the clinical settings for treatment of patients with heart failure, pulmonary hypertension, and coronary artery disease”. For more see: https://jeffreydachmd.com/making-coff...
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7) O’Keefe, James H., James J. DiNicolantonio, and Carl J. Lavie. “Coffee for cardioprotection and longevity.” Progress in cardiovascular diseases (2018).
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee’s effects on arrhythmias and hypertension are neutral. Coffee consumption is associated with improvements in some CV risk factors, including type 2 diabetes (T2D), depression, and obesity. Chronic coffee consumption also appears to protect against some neurodegenerative diseases, and is associated with improved asthma control, and lower risks for liver disease and cancer. Habitual intake of 3 to 4 cups of coffee appears to be safe and is associated with the most robust beneficial effects. However, most of the studies regarding coffee’s health effects are based on observational data, with very few randomized controlled trials. Furthermore, the possible benefits of coffee drinking must be weighed against potential risks, which are generally due to its high caffeine content, including anxiety, insomnia, headaches, tremulousness, and palpitations. Coffee may also increase risk of fracture in women, and when consumed in pregnancy coffee increases risk for low birth weight and preterm labor.
8) Wierzejska, Regina. “Can coffee consumption lower the risk of Alzheimer’s disease and Parkinson’s disease? A literature review.” Archives of medical science: AMS 13.3 (2017): 507.
Most reports indicate that moderate coffee consumption may in fact lower the risk for common neurodegenerative conditions, i.e. Alzheimer’s and Parkinson’s diseases.
9) Poole, Robin, et al. “Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.” bmj 359 (2017): j5024.
Objectives To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes. Design Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome. Data sources PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references.
Eligibility criteria for selecting studies Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings. Studies of genetic polymorphisms for coffee metabolism were excluded.
Results The umbrella review identified 201 meta-analyses of observational research with 67 unique health outcomes and 17 meta-analyses of interventional research with nine unique outcomes. Coffee consumption was more often associated with benefit than harm for a range of health outcomes across exposures including high versus low, any versus none, and one extra cup a day. There was evidence of a non-linear association between consumption and some outcomes, with summary estimates indicating largest relative risk reduction at intakes of three to four cups a day versus none, including all cause mortality (relative risk 0.83, 95% confidence interval 0.83 to 0.88), cardiovascular mortality (0.81, 0.72 to 0.90), and cardiovascular disease (0.85, 0.80 to 0.90). High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89). Consumption was also associated with a lower risk of several specific cancers and neurological, metabolic, and liver conditions. Harmful associations were largely nullified by adequate adjustment for smoking, except in pregnancy, where high versus low/no consumption was associated with low birth weight (odds ratio 1.31, 95% confidence interval 1.03 to 1.67), preterm birth in the first (1.22, 1.00 to 1.49) and second (1.12, 1.02 to 1.22) trimester, and pregnancy loss (1.46, 1.06 to 1.99). There was also an association between coffee drinking and risk of fracture in women but not in men.
Conclusion Coffee consumption seems generally safe within usual levels of intake, with summary estimates indicating largest risk reduction for various health outcomes at three to four cups a day, and more likely to benefit health than harm. Robust randomised controlled trials are needed to understand whether the observed associations are causal. Importantly, outside of pregnancy, existing evidence suggests that coffee could be tested as an intervention without significant risk of causing harm. Women at increased risk of fracture should possibly be excluded.
10) Gunter, Marc J., et al. “Coffee drinking and mortality in 10 European countries: a multinational cohort study.” Annals of internal medicine 167.4 (2017): 236-247.
The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear.
Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality.
Design: Prospective cohort study.
Setting: 10 European countries.
Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition).
Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800).
Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels.
Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once.
Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
11) Ann Intern Med. 2017 Aug 15;167(4):228-235. Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations.
Park SY1, Freedman ND1, Haiman CA1, Le Marchand L1, Wilkens LR1, Setiawan VW1.
Coffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse.
Objective: To examine the association of coffee consumption with risk for total and cause-specific death.
Design: The MEC (Multiethnic Cohort), a prospective population-based cohort study established between 1993 and 1996.
Setting: Hawaii and Los Angeles, California.
Participants: 185 855 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites aged 45 to 75 years at recruitment.
Measurements: Outcomes were total and cause-specific mortality between 1993 and 2012. Coffee intake was assessed at baseline by means of a validated food-frequency questionnaire.
Results: 58 397 participants died during 3 195 484 person-years of follow-up (average follow-up, 16.2 years). Compared with drinking no coffee, coffee consumption was associated with lower total mortality after adjustment for smoking and other potential confounders (1 cup per day: hazard ratio [HR], 0.88 [95% CI, 0.85 to 0.91]; 2 to 3 cups per day: HR, 0.82 [CI, 0.79 to 0.86]; ≥4 cups per day: HR, 0.82 [CI, 0.78 to 0.87]; P for trend < 0.001). Trends were similar between caffeinated and decaffeinated coffee. Significant inverse associations were observed in 4 ethnic groups; the association in Native Hawaiians did not reach statistical significance. Inverse associations were also seen in never-smokers, younger participants (<55 years), and those who had not previously reported a chronic disease. Among examined end points, inverse associations were observed for deaths due to heart disease, cancer, respiratory disease, stroke, diabetes, and kidney disease.
Limitation: Unmeasured confounding and measurement error, although sensitivity analysis suggested that neither was likely to affect results.
Conclusion: Higher consumption of coffee was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whites.
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The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
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(c) 2013-2017 Jeffrey Dach MD All Rights Reserved All Images are in the public domain courtesy wikimedia commons
Published on September 15th, 2023 by Jeffrey Dach MD
The post Making Coffee Out of This World by Jeffrey Dach MD appeared first on Jeffrey Dach MD.
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