Really enjoyed the book. After reading Transcend by Kurzweil some of the points in End of Illness felt less fleshed out and more elementary, so I'd recommend Transcend overall. This book's strength is the idea that the body is a complex, interrelated system and that the diseases that confront us today are a malfunction of that system and will not have a magic bullet line polio or antibiotics. We need to control our health through the interventions we know work (I.e. diet, exercise, sleep, routines, stress, etc.) while we wait for the next generation medical technologies coming in 10-30 years which will change everything. I also appreciate his argument to "do nothing" and put less trust in supplements and focus more on good food. I think that's a smarter path forward for younger people like me (if I was middle aged I might consider supplementation more seriously) is little to no supplementation.