I've always loved Kerouac and this book made me love him even more. It's so honest and heartfelt. Even though everyone in the novel (Kerouac included) has problems, he doesn't say anything bad about them. That is true for all of Kerouac's books I've read: he gives people respect, even if they are addicted to morphine, etc.
Kerouac too had his fair share of demons and problems with substance abuse and he knows this. He is honest and open about what he thinks and feels, and Tristessa is a perfect example of this. His writing style is fluid and beautiful. Needless to say, I highly recommend this book.