While I was reading this, I was thinking of Octavia Butler's Xenogenisis trilogy, and many of the questions she brought up about what makes something a human.
What can you change about humans and still have a human?
Their minds? Their sex drives? Skin color? Hair? Society? Their instincts?
Are Crake's creations still human? Does it matter? Atwood didn't consider any of these questions in any meaningful way. I think I liked Butler's more thoughtful treatment of some of the material rather than Atwood's "Let's see if this shocks them!" style.
But overall, I still enjoyed Atwood's book more - though not quite as much as The Handmaid's Tale.