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The Music of Life: Biology Beyond the Genome

3.66  ·  Rating Details ·  152 Ratings  ·  17 Reviews
Inquebrantable por naturaleza nos regala tres diferentes historias que marcaron la vida de una misma persona.
Primero, nos narra los deseos que un niño de nueve años tiene para sobrevivir al maltrato y a los obstáculos que la vida puso en su camino a tan temprana edad. Después de haber ganado la batalla contra la garganta del infierno –un pozo de veintitrés metros de profun
Hardcover, 153 pages
Published July 1st 2006 by Oxford University Press, USA (first published June 8th 2006)
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Jan 06, 2013 Peter rated it it was amazing  ·  review of another edition
Recommends it for: Anybody interested in life science and origins
The whole is greater than the sum of it's parts.
"The music of life is a symphony. It has many different movements. Some melodies find echoes in more than one, but the movements are non the less distinct."
I don't want to over sell this book but it is fantastic stuff, combining the learnedness of Carl Segan with the conversational readability of Bill Bryson. It is so well written in fact, that on closing it I immediately google-searched (note the new verb) for anything else that he has written. It
Jul 13, 2008 Kate rated it liked it
Denis Noble, professor emeritus (Oxford), writes a polemical response to Dawkins' The Selfish Gene. Dawkins has been crowned, rightly or wrongly, King of the Genetic Reductionists (that who we are, what we do, how we feel, and what diseases we get are a function of our genes). Noble, on the other hand, makes an impassioned plea for a more wholistic approach to understanding what Life is, and therefore thinks in terms of systems rather than genes. In doing this, he employs musical metaphors in ea ...more
Dec 03, 2014 Jeannie rated it it was amazing  ·  review of another edition
In The Music of Life, Denis Noble argues for an integrative systems approach to evolutionary biology to complement the reductionist gene’s eye view that has prevailed throughout the past century. He begins by evaluating and reconstructing the framework of the metaphor used by Richard Dawkins in The Selfish Gene to illustrate both the limitations of the gene-centric perspective and of the reliance on literary devices to convey scientific ideology. Noble elegantly moves outward from the genome, th ...more
Justin Covey
Jan 05, 2015 Justin Covey rated it really liked it  ·  review of another edition
Intriguing counter point to the popular gene determinist view of biology. We commonly think of DNA as the great determinator of life as it's the pathway of heredity and evolution, but Noble makes the case that DNA alone cannot do this. That it is virtually impossible to recreate an organism solely from its DNA, without also the egg cell and an understanding of the organisms embryonic conditions. In Noble's central metaphor DNA is not the program or plan it is normally imagined to be, but instead ...more
Theresa Truax-Gischler
Must-read integrative systems approach to human biology. The systems approach is an important antidote to the reductionist bottom-up or top-down approaches that have typified the major debates of our times—nature versus nurture, genes versus epigenetics, structure versus function, innate versus environmental. Noble's book should be basic theoretical reading for anyone studying human development, presenting in clear language the basic tenets of dynamic, integrative systems concepts. Very good to ...more
Joseph D. Walch
Apr 20, 2010 Joseph D. Walch rated it really liked it  ·  review of another edition
Like New York City or the most complex space satellite, every cell in our bodies contain tens of thousands of moving parts that serve myriad functions. On top of that, these cells organize differently in groups to form functional organs which are in turn dependant on other organs in a system that sustains intelligent life. This book is the story of the delicate yet amazingly orchestrated biological systems that form the foundation of life.

This is a very interesting book that explores the paradig
Jun 13, 2013 Roger rated it liked it  ·  review of another edition
I was a little disappointed with this book. It contains some good and thought provoking information on systems biology and on the expression and regulation of genes, but I found it rather slow moving and laboured. In my opinion, the author placed too much emphasis on using metaphors to explain the points he was trying to make (which, in fairness, he stated was his intent). I often found these confusing and I would rather have just had a presentation of his understanding of the mechanisms at play ...more
J Scott Shipman
Nov 14, 2011 J Scott Shipman rated it really liked it  ·  review of another edition
Denis Noble has given us a powerful little book to frame our notion of the appropriate role of the genome in science. His approach is called an integrative systems approach and make a lot sense. Instead of the reductionist certainty plaguing the science genetics, Noble encourages a different tack. His use of metaphor and analogy is both illuminating and entertaining; I found his use of music to be the most compelling.

I purchased this book because I've been studying the application of metaphors
Tjibbe Wubbels
Is this book about system biology? Or is it about language or more specifically metaphors? I really enjoyed the introduction and first chapter in which Mr Noble explains his theory. After that the theory gets repeated for different `levels of life` (cell, organ etc). Luckily for the reader it is repeated using these nice metaphors that keep you reading. In the last two chapters it becomes more vague and philosophical. It`s about the self being a process rather then an object. I guess it`s the ul ...more
Apr 09, 2010 Ruban rated it really liked it
The book is a brain-stretching delight: an impassioned attack on narrow thinking regarding evolution, whether from the general media or other, specialised scientists.. What makes this book interesting is the combination of state of the art knowledge in many totally different fields - it is rare to find a book with so many well founded and important philosophical implications of the scientific discoveries in our time.
Juan F. Abenza
Reductionism is bad. Noble starts insisting very much in the fact that the scientific approaches are changing to became more wholistic, giving some redundant examples, and ends with a very interesting philosophical dissertation about the existence of the "self", the neo-dualism and the ways our language conditions us in our perception of the things. Worth reading it.
Alessio Franci
Epigenesis, explained with beautiful metaphor
The last chapter brain/intelligence probably deserves more attention...
Ian Harrow
Jan 06, 2013 Ian Harrow rated it really liked it  ·  review of another edition
Shelves: science
An enjoyable and stimulating polemic discussion about processes of life which uses music as metaphor.
Sep 08, 2011 Xin rated it liked it  ·  review of another edition
The book has some parts on the latest research developments, but overall is not particularly informative if you have some biology background.
Rohit rated it it was amazing
Mar 01, 2015
Jennifer Chang
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Dec 28, 2012
Arunachalam Bharathi
A great book... a must read for any one interested in life.
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Denis Noble is Emeritus Professor of Cardiovascular Physiology. He now directs the computational physiology research group. He was the first to model cardiac cells (in two papers in Nature in 1960) and has published over 350 research papers. He is one of the leaders of Systems Biology and has written the first popular book on Systems Biology, The MUSIC of LIFE (OUP, 2006).

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“Quite soon, as we move from genes to the proteins that they code for, and then on to the interactions between these proteins, the problems become seriously complicated.” 0 likes
“Much contemporary popular writing on genetics assumes that it should be possible to reconstruct living systems from the bottom up, starting with the raw DNA code. And that is precisely the sort of procedure we have just seen to be so entirely impracticable. Clearly, we need first to narrow the options. And there is only one way to do that; we must observe how nature itself has narrowed the options.” 0 likes
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